Version 5.4
Mus musculus Gene: Vps25
Summary
InnateDB Gene IDBG-267009.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Vps25
Gene Name vacuolar protein sorting 25 (yeast)
Synonyms 1110020N13Rik; AW107467; D11Wsu68e
Species Mus musculus
Ensembl Gene ENSMUSG00000078656
Encoded Proteins
IDBP-211996
vacuolar protein sorting 25 (yeast)
IDBP-211998
vacuolar protein sorting 25 (yeast)
IDBP-212000
vacuolar protein sorting 25 (yeast)
IDBP-267011
vacuolar protein sorting 25 (yeast)
IDBP-400063
vacuolar protein sorting 25 (yeast)
IDBP-627622
vacuolar protein sorting 25 (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000131475:
VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS25, VPS36, and SNF8 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:101253707-101259549
Strand Forward strand
Band D
Transcripts
ENSMUST00000007533 ENSMUSP00000007533
ENSMUST00000100414 ENSMUSP00000097981
ENSMUST00000042477 ENSMUSP00000042088
ENSMUST00000107280 ENSMUSP00000102901
ENSMUST00000121331 ENSMUSP00000114100
ENSMUST00000144306 ENSMUSP00000131026
ENSMUST00000123529
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0015031 protein transport
Cellular Component
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0010008 endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000131475
View Gene Order
ENSBTAG00000019906
Not yet available
Pathways
NETPATH
REACTOME
REACT_209837
Membrane Trafficking pathway
REACT_198518
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
KEGG
mmu04144
Endocytosis pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_11123
Membrane Trafficking pathway
REACT_212419
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_213260
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt Q9CQ80
TrEMBL A8XY17
UniProt Splice Variant
Entrez Gene 28084
UniGene
RefSeq NM_026776 NM_001284411 NM_001284412 NM_001284414
OMIM
CCDS CCDS25458 CCDS70311 CCDS70312 CCDS70313
HPRD
IMGT
MGI ID MGI:106354
MGI Symbol Vps25
EMBL AK002500 AK003715 AK003877 AK145811 AK150822 AK166008 AL590969 BC029181
GenPept AAH29181 BAB22148 BAB22955 BAB23054 BAE26665 BAE29884 BAE38516 CAM19564 CAM19566
RNA Seq Atlas 28084

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca