Version 5.4
Homo sapiens Gene: VPS25
Summary
InnateDB Gene IDBG-51652.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VPS25
Gene Name vacuolar protein sorting 25 homolog (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131475
Encoded Proteins
IDBP-51654
vacuolar protein sorting 25 homolog (S. cerevisiae)
IDBP-760716
IDBP-763051
IDBP-760535
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary VPS25, VPS36 (MIM 610903), and SNF8 (MIM 610904) form ESCRT-II (endosomal sorting complex required for transport II), a complex involved in endocytosis of ubiquitinated membrane proteins. VPS25, VPS36, and SNF8 are also associated in a multiprotein complex with RNA polymerase II elongation factor (ELL; MIM 600284) (Slagsvold et al., 2005 [PubMed 15755741]; Kamura et al., 2001 [PubMed 11278625]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42773436-42779599
Strand Forward strand
Band q21.2
Transcripts
ENST00000253794 ENSP00000253794
ENST00000591584
ENST00000589577 ENSP00000467225
ENST00000589520 ENSP00000465798
ENST00000589219
ENST00000590339 ENSP00000466909
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:0061024 membrane organization
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0010008 endosome membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078656
View Gene Order
ENSBTAG00000019906
Not yet available
Pathways
NETPATH
REACTOME
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 84313
UniGene
RefSeq NM_032353
HUGO HGNC:28122
OMIM 610907
CCDS CCDS11438
HPRD 14396
IMGT
EMBL
GenPept
RNA Seq Atlas 84313

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca