Version 5.4
Homo sapiens Gene: ALG10B
Summary
InnateDB Gene IDBG-26732.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALG10B
Gene Name asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000175548
Encoded Proteins
IDBP-26734
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast)
IDBP-591800
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast)
IDBP-599030
asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a membrane-associated protein that adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. That is, it transfers the terminal glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc2Man9GlcNAc(2)-PP-Dol. The rat protein homolog was shown to specifically modulate the gating function of the rat neuronal ether-a-go-go (EAG) potassium ion channel. [provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:38316578-38329728
Strand Forward strand
Band q12
Transcripts
ENST00000308742 ENSP00000310120
ENST00000551464 ENSP00000448819
ENST00000553138
ENST00000548240 ENSP00000449210
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016758 transferase activity, transferring hexosyl groups
Biological Process
GO:0006488 dolichol-linked oligosaccharide biosynthetic process
GO:0008152 metabolic process
GO:0018279 protein N-linked glycosylation via asparagine
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_22433
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein pathway
REACT_22426
Asparagine N-linked glycosylation pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00510
N-Glycan biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL F8VXJ0
UniProt Splice Variant
Entrez Gene 144245
UniGene Hs.102971 Hs.259305
RefSeq NM_001013620 XM_005268665 XM_006719243
HUGO HGNC:31088
OMIM 603313
CCDS CCDS31772
HPRD 11923
IMGT
EMBL AC117372
GenPept
RNA Seq Atlas 144245

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca