InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ALG10B

Summary

InnateDB Protein

IDBP-26734.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ALG10B

Protein Name

asparagine-linked glycosylation 10, alpha-1,2-glucosyltransferase homolog B (yeast)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000310120

InnateDB Gene

IDBG-26732 (ALG10B)

Protein Structure

UniProt Annotation

Function

Putative alpha-1,2-glucosyltransferase, which adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol. When coupled to KCNH2 may reduce KCNH2 sensitivity to classic proarrhythmic drug blockade, possibly by mediating glycosylation of KCNH2. {ECO:0000269PubMed:14525949}.

Subcellular Localization

Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.

Disease Associations

Tissue Specificity

Highly expressed in heart, placenta, liver, kidney and pancreas. Weakly expressed in lung, skeletal muscle and brain. {ECO:0000269PubMed:14525949}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016758	transferase activity, transferring hexosyl groups

Biological Process

GO:0006488	dolichol-linked oligosaccharide biosynthetic process
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process