Homo sapiens Gene: SRCAP

Summary
InnateDB Gene IDBG-26746.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol SRCAP
Gene Name Snf2-related CREBBP activator protein
Synonyms DOMO1; EAF1; FLHS; SWR1
Species Homo sapiens
Ensembl Gene ENSG00000080603
Encoded Proteins
IDBP-26748 Snf2-related CREBBP activator protein
IDBP-26750 Snf2-related CREBBP activator protein
IDBP-26752 Snf2-related CREBBP activator protein
IDBP-240301 Snf2-related CREBBP activator protein
IDBP-375402 Snf2-related CREBBP activator protein
Entrez Gene
Summary This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16: 30709530-30755602
Strand Forward strand
Band p11.2
Transcripts
ENST00000380361  ENSP00000369719
ENST00000344771  ENSP00000343042
ENST00000262518  ENSP00000262518
ENST00000395059  ENSP00000378499
ENST00000411466  ENSP00000405186
ENST00000483083 
ENST00000474008 
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein‑Protein  32
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0004386 helicase activity
GO:0004402 histone acetyltransferase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 transcription, DNA-dependent
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0016573 histone acetylation
GO:0019048 virus-host interaction
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000053877 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000013917 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q6ZRS2 
TrEMBL C9J4U4 G1UI29
UniProt Splice Variant
Entrez Gene 10847 
UniGene Hs.627410 Hs.647334
RefSeq NM_006662 
HUGO 16974 
OMIM 611421
CCDS CCDS10689 
HPRD 18103
IMGT
EMBL AB002307 AB621816 AC093249 AC106886 AF143946 AK128030 BC159099
GenPept AAD39760  AAI59100  BAA20768  BAC87237  BAK64152 
ImmGen SRCAP (murine) 
RNA Seq Atlas 10847