Homo sapiens Gene: SRCAP
Summary
InnateDB Gene IDBG-26746.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SRCAP
Gene Name Snf2-related CREBBP activator protein
Synonyms DOMO1; EAF1; FLHS; SWR1;
Species Homo sapiens
Ensembl Gene ENSG00000080603
Encoded Proteins
Snf2-related CREBBP activator protein
Snf2-related CREBBP activator protein
Snf2-related CREBBP activator protein
Snf2-related CREBBP activator protein
Snf2-related CREBBP activator protein
Snf2-related CREBBP activator protein
Protein Structure
Entrez Gene
Summary This gene encodes the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex. The encoded protein is an ATPase that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. It can function as a transcriptional activator in Notch-mediated, CREB-mediated and steroid receptor-mediated transcription. Mutations in this gene cause Floating-Harbor syndrome, a rare disorder characterized by short stature, language deficits and dysmorphic facial features. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30698209-30745194
Strand Forward strand
Band p11.2
Transcripts
ENST00000380361 ENSP00000369719
ENST00000262518 ENSP00000262518
ENST00000395059 ENSP00000378499
ENST00000411466 ENSP00000405186
ENST00000483083 ENSP00000483329
ENST00000474008
ENST00000615541 ENSP00000477871
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 28 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003713 transcription coactivator activity
GO:0004386 helicase activity
GO:0004402 histone acetyltransferase activity
GO:0005524 ATP binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0009607 response to biotic stimulus
GO:0016032 viral process
GO:0016573 histone acetylation
Cellular Component
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Cross-References
SwissProt Q6ZRS2
TrEMBL C9J4U4 G1UI29
UniProt Splice Variant
Entrez Gene 10847
UniGene Hs.627410 Hs.647334
RefSeq NM_001256829 NM_006662
HUGO HGNC:16974
OMIM 611421
CCDS CCDS10689 CCDS73870
HPRD 18103
IMGT
EMBL AB002307 AB621816 AC093249 AC106886 AF143946 AK128030 BC159099
GenPept AAD39760 AAI59100 BAA20768 BAC87237 BAK64152
ImmGen SRCAP (murine)
RNA Seq Atlas 100862671 10847