InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: SRCAP

Summary

InnateDB Protein

IDBP-26752.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SRCAP

Protein Name

Snf2-related CREBBP activator protein

Synonyms

DOMO1; EAF1; FLHS; SWR1;

Species

Homo sapiens

Ensembl Protein

ENSP00000262518

InnateDB Gene

IDBG-26746 (SRCAP)

Protein Structure

UniProt Annotation

Function

Catalytic component of the SRCAP complex which mediates the ATP-dependent exchange of histone H2AZ/H2B dimers for nucleosomal H2A/H2B, leading to transcriptional regulation of selected genes by chromatin remodeling. Acts as a coactivator for CREB-mediated transcription, steroid receptor-mediated transcription, and Notch-mediated transcription. {ECO:0000269PubMed:10347196, ECO:0000269PubMed:11522779, ECO:0000269PubMed:14500758, ECO:0000269PubMed:16024792, ECO:0000269PubMed:16634648, ECO:0000269PubMed:17617668}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00549, ECO:0000269PubMed:10702287}.

Disease Associations

Floating-Harbor syndrome (FLHS) [MIM:136140]: A rare genetic disorder characterized by proportionate short stature, delayed bone age, delayed speech development, and typical facial features. The face is triangular with deep-set eyes, long eyelashes, bulbous nose, wide columella, short philtrum, and thin lips. {ECO:0000269PubMed:22265015}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0004386	helicase activity
GO:0004402	histone acetyltransferase activity
GO:0005524	ATP binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0016032	viral process
GO:0016573	histone acetylation

Cellular Component

GO:0005634	nucleus
GO:0005794	Golgi apparatus
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

InterPro

IPR000330 SNF2-related
IPR001650 Helicase, C-terminal
IPR013999 HAS subgroup
IPR014001 Helicase, superfamily 1/2, ATP-binding domain
IPR014012 Helicase/SANT-associated, DNA binding
IPR017956 AT hook, DNA-binding motif
IPR020478 AT hook-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

PFAM

PF00176
PF00271
PF07529
PF02178

PRINTS

PR00929

PIRSF

SMART

SM00490
SM00573
SM00487
SM00384

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt