Version 5.4
Mus musculus Gene: Ube2d3
Summary
InnateDB Gene IDBG-269073.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ube2d3
Gene Name ubiquitin-conjugating enzyme E2D 3
Synonyms 1100001F19Rik; 9430029A22Rik; AA414951
Species Mus musculus
Ensembl Gene ENSMUSG00000078578
Encoded Proteins
IDBP-269075
ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
IDBP-620911
ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 3:135438297-135467178
Strand Forward strand
Band G3
Transcripts
ENSMUST00000106291 ENSMUSP00000101898
ENSMUST00000166033 ENSMUSP00000130096
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016881 acid-amino acid ligase activity
Biological Process
GO:0000209 protein polyubiquitination
GO:0006281 DNA repair
GO:0006513 protein monoubiquitination
GO:0006915 apoptotic process
GO:0016567 protein ubiquitination
GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process
GO:0070936 protein K48-linked ubiquitination
GO:0070979 protein K11-linked ubiquitination
Cellular Component
GO:0005575 cellular_component
GO:0005886 plasma membrane
GO:0010008 endosome membrane
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_217958
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_263316
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_239142
Innate Immune System pathway
REACT_189085
Disease pathway
REACT_188957
Cellular responses to stress pathway
REACT_215068
Loss of Function of SMAD4 in Cancer pathway
REACT_199106
Cellular response to hypoxia pathway
REACT_213336
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_220505
Signaling by BMP pathway
REACT_224217
TGFBR1 LBD Mutants in Cancer pathway
REACT_198532
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_230745
Immune System pathway
REACT_199108
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_199109
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_220566
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_204241
Loss of Function of TGFBR2 in Cancer pathway
REACT_216792
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_224787
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_251547
Toll-Like Receptors Cascades pathway
REACT_233572
Gene Expression pathway
REACT_223317
Loss of Function of TGFBR1 in Cancer pathway
REACT_262462
Activated TLR4 signalling pathway
REACT_226192
IKK complex recruitment mediated by RIP1 pathway
REACT_209370
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_202264
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_206529
Generic Transcription Pathway pathway
REACT_241786
MyD88-independent cascade pathway
REACT_188257
Signal Transduction pathway
REACT_224802
TGFBR1 KD Mutants in Cancer pathway
REACT_219118
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_212101
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_238546
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_225428
Signaling by TGF-beta Receptor Complex pathway
REACT_226256
Loss of Function of SMAD2/3 in Cancer pathway
REACT_246719
Toll Like Receptor 4 (TLR4) Cascade pathway
KEGG
mmu04120
Ubiquitin mediated proteolysis pathway
mmu04141
Protein processing in endoplasmic reticulum pathway
INOH
PID NCI
Cross-References
SwissProt P61079
TrEMBL Q4QQL2
UniProt Splice Variant
Entrez Gene 66105
UniGene Mm.429871 Mm.49884
RefSeq NM_025356 XM_006501873 XM_006501874 XM_006501875 XM_006501876
OMIM
CCDS CCDS38644
HPRD
IMGT
MGI ID MGI:1913355
MGI Symbol Ube2d3
EMBL AK004001 AK032885 AK049906 AK077666 AK088448 AK151295 AK151594 AK152541 AK153100 AK153111 AK159125 AK159546 AK159963 AK165235 AK167077 AK167138 AK167650 AK167801 AK169177 BC057941 BC098220 CH466532
GenPept AAH57941 AAH98220 BAB23116 BAC28070 BAC33981 BAC36940 BAC40357 BAE30279 BAE30534 BAE31296 BAE31721 BAE31728 BAE34839 BAE35172 BAE35518 BAE38093 BAE39237 BAE39283 BAE39701 BAE39829 BAE40955 EDL12149 EDL12150 EDL12151 EDL12152 EDL12153
RNA Seq Atlas 66105

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca