InnateDB Protein
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IDBP-269075.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Ube2d3
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Protein Name
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ubiquitin-conjugating enzyme E2D 3 (UBC4/5 homolog, yeast)
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Synonyms
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1100001F19Rik; 9430029A22Rik; AA414951;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000101898
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InnateDB Gene
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IDBG-269073 (Ube2d3)
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Protein Structure
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Function |
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the polyubiquitination of NFKBIA leading to its subsequent proteasomal degradation. Acts as an initiator E2, priming the phosphorylated NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a monoubiquitin. Ubiquitin chain elongation is then performed by CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA- linked ubiquitin. Acts also as an initiator E2, in conjunction with RNF8, for the priming of PCNA. Monoubiquitination of PCNA, and its subsequent polyubiquitination, are essential events in the operation of the DNA damage tolerance (DDT) pathway that is activated after DNA damage caused by UV or chemical agents during S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to perform ubiquitination at DNA damage sites following ionizing radiation leading to DNA repair. Targets DAPK3 for ubiquitination which influences promyelocytic leukemia protein nuclear body (PML- NB) formation in the nucleus. In conjunction with the MDM2 and TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports NRDP1-mediated ubiquitination and degradation of ERBB3 and of BRUCE which triggers apoptosis. In conjunction with the CBL E3 ligase, targets EGFR for polyubiquitination at the plasma membrane as well as during its internalization and transport on endosomes. In conjunction with the STUB1 E3 quality control E3 ligase, ubiquitinates unfolded proteins to catalyze their immediate destruction (By similarity). {ECO:0000250}.
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Subcellular Localization |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1913355
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InterPro |
IPR000608
Ubiquitin-conjugating enzyme, E2
IPR016135
Ubiquitin-conjugating enzyme/RWD-like
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PFAM |
PF00179
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P61079
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PhosphoSite |
PhosphoSite-P61079
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TrEMBL |
Q4QQL2
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UniProt Splice Variant |
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Entrez Gene |
66105
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UniGene |
Mm.49884
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RefSeq |
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MGI ID |
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MGI Symbol |
Ube2d3
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OMIM |
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CCDS |
CCDS38644
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HPRD |
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IMGT |
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EMBL |
AK004001
AK032885
AK049906
AK077666
AK088448
AK151295
AK151594
AK152541
AK153100
AK153111
AK159125
AK159546
AK159963
AK165235
AK167077
AK167138
AK167650
AK167801
AK169177
BC057941
BC098220
CH466532
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GenPept |
AAH57941
AAH98220
BAB23116
BAC28070
BAC33981
BAC36940
BAC40357
BAE30279
BAE30534
BAE31296
BAE31721
BAE31728
BAE34839
BAE35172
BAE35518
BAE38093
BAE39237
BAE39283
BAE39701
BAE39829
BAE40955
EDL12149
EDL12150
EDL12151
EDL12152
EDL12153
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