InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Mos

Summary

InnateDB Gene

IDBG-271528.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mos

Gene Name

Moloney sarcoma oncogene

Synonyms

c-mos

Species

Mus musculus

Ensembl Gene

ENSMUSG00000078365

Encoded Proteins

IDBP-271530

Moloney sarcoma oncogene

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000172680:
MOS is a serine/threonine kinase that activates the MAP kinase cascade through direct phosphorylation of the MAP kinase activator MEK (MAP2K1; MIM 176872) (Prasad et al., 2008 [PubMed 18246541]).[supplied by OMIM, Jul 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:3870657-3872105

Strand

Reverse strand

Band

Transcripts

ENSMUST00000105158

ENSMUSP00000100789

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004709	MAP kinase kinase kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000186	activation of MAPKK activity
GO:0000187	activation of MAPK activity
GO:0000212	meiotic spindle organization
GO:0006325	chromatin organization
GO:0006468	protein phosphorylation
GO:0040020	regulation of meiosis
GO:0046777	protein autophosphorylation
GO:0051296	establishment of meiotic spindle orientation
GO:1902103	negative regulation of metaphase/anaphase transition of meiotic cell cycle