Version 5.4
Mus musculus Gene: Hmga1-rs1
Summary
InnateDB Gene IDBG-271878.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Hmga1-rs1
Gene Name high mobility group AT-hook I, related sequence 1
Synonyms AL023995; ENSMUSG00000041059; Hmga1a; Hmga1b; Hmgi; Hmgi-rs1; Hmgiy; Hmgy
Species Mus musculus
Ensembl Gene ENSMUSG00000078249
Encoded Proteins
IDBP-271880
high mobility group AT-hook I, related sequence 1
IDBP-718815
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This locus encodes a member of the nuclear, non-histone high mobility group protein family. This architectural transcription factor binds to A-T rich DNA sequences and participates in enhanceosome formation, chromatin remodeling and regulation of transcription. This protein functions in many cellular processes, including cell growth and differentiation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Oct 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:120762794-120764419
Strand Forward strand
Band E2
Transcripts
ENSMUST00000105046 ENSMUSP00000100667
ENSMUST00000178955 ENSMUSP00000137252
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0030374 ligand-dependent nuclear receptor transcription coactivator activity
GO:0042974 retinoic acid receptor binding
GO:0042975 peroxisome proliferator activated receptor binding
GO:0046965 retinoid X receptor binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0008285 negative regulation of cell proliferation
GO:0035986 senescence-associated heterochromatin focus assembly
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0090402 oncogene-induced cell senescence
GO:2000774 positive regulation of cellular senescence
Cellular Component
GO:0005634 nucleus
GO:0035985 senescence-associated heterochromatin focus
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_188957
Cellular responses to stress pathway
REACT_188819
DNA Damage/Telomere Stress Induced Senescence pathway
REACT_188820
Cellular Senescence pathway
REACT_209428
Formation of Senescence-Associated Heterochromatin Foci (SAHF) pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P17095
TrEMBL J3QK51 Q3TE85 Q566K0
UniProt Splice Variant
Entrez Gene 15361
UniGene
RefSeq NM_001166476 NM_001166477
OMIM
CCDS CCDS49010
HPRD
IMGT
MGI ID MGI:96161
MGI Symbol Hmga1-rs1
EMBL AF285780 AK010617 AK154957 AK169783 AK171334 AL663090 BC013455 BC093496 J04179
GenPept AAA37820 AAH13455 AAH93496 AAK66158 AAK66159 BAB27065 BAE32952 BAE41363 BAE42398
RNA Seq Atlas 111241 15361

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca