InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Hmga1-rs1

Summary

InnateDB Protein

IDBP-271880.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Hmga1-rs1

Protein Name

high mobility group AT-hook I, related sequence 1

Synonyms

AL023995; ENSMUSG00000041059; Hmga1a; Hmga1b; Hmgi; Hmgi-rs1; Hmgiy; Hmgy;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000100667

InnateDB Gene

IDBG-271878 (Hmga1-rs1)

Protein Structure

UniProt Annotation

Function

HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.

Subcellular Localization

Nucleus. Chromosome.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0008134	transcription factor binding
GO:0030374	ligand-dependent nuclear receptor transcription coactivator activity
GO:0042974	retinoic acid receptor binding
GO:0042975	peroxisome proliferator activated receptor binding
GO:0046965	retinoid X receptor binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0008285	negative regulation of cell proliferation
GO:0035986	senescence-associated heterochromatin focus assembly
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045893	positive regulation of transcription, DNA-templated
GO:0090402	oncogene-induced cell senescence
GO:2000774	positive regulation of cellular senescence