Homo sapiens Gene: KCNE2

Summary
InnateDB Gene IDBG-2733.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol KCNE2
Gene Name potassium voltage-gated channel, Isk-related family, member 2
Synonyms ATFB4; LQT5; LQT6; MIRP1
Species Homo sapiens
Ensembl Gene ENSG00000159197
Encoded Proteins
IDBP-2735 potassium voltage-gated channel, Isk-related family, member 2
Entrez Gene
Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21: 35736323-35743440
Strand Forward strand
Band q22.11
Transcripts
ENST00000290310  ENSP00000290310
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein‑Protein  1
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006936 muscle contraction
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0034613 cellular protein localization
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0071805 potassium ion transmembrane transport
GO:0086005 regulation of ventricular cardiac muscle cell action potential
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000039672 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000026260 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
hsa04971  Gastric acid secretion
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y6J6 
TrEMBL Q2N1I3
UniProt Splice Variant
Entrez Gene 9992 
UniGene Hs.736062
RefSeq NM_172201 
HUGO 6242 
OMIM 603796
CCDS CCDS13635 
HPRD 04813
IMGT
EMBL AF071002 AF302095 BC093892 BC112087 CH471079 DQ192290 DQ784804
GenPept AAD28086  AAG13416  AAH93892  AAI12088  ABB00303  ABQ01239  EAX09791 
ImmGen KCNE2 (murine) 
RNA Seq Atlas 9992