Homo sapiens Gene: KCNE2
Summary
InnateDB Gene IDBG-2733.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol KCNE2
Gene Name potassium voltage-gated channel, Isk-related family, member 2
Synonyms ATFB4; LQT5; LQT6; MIRP1;
Species Homo sapiens
Ensembl Gene ENSG00000159197
Encoded Proteins
potassium voltage-gated channel, Isk-related family, member 2
Protein Structure
Entrez Gene
Summary Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:35736323-35743440
Strand Forward strand
Band q22.11
Transcripts
ENST00000290310 ENSP00000290310
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0006936 muscle contraction
GO:0008015 blood circulation
GO:0008016 regulation of heart contraction
GO:0034613 cellular protein localization
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0071805 potassium ion transmembrane transport
GO:0086005 regulation of ventricular cardiac muscle cell action potential
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0016020 membrane
GO:0016021 integral to membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
KEGG
Gastric acid secretion pathway
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9Y6J6
TrEMBL Q2N1I3
UniProt Splice Variant
Entrez Gene 9992
UniGene Hs.736062
RefSeq NM_172201
HUGO 6242
OMIM 603796
CCDS CCDS13635
HPRD 04813
IMGT
EMBL AF071002 AF302095 BC093892 BC112087 CH471079 DQ192290 DQ784804
GenPept AAD28086 AAG13416 AAH93892 AAI12088 ABB00303 ABQ01239 EAX09791
ImmGen KCNE2 (murine)
RNA Seq Atlas 9992