Version 5.4
Mus musculus Gene: Kcne2
Summary
InnateDB Gene IDBG-177527.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Kcne2
Gene Name potassium voltage-gated channel, Isk-related subfamily, gene 2
Synonyms
Species Mus musculus
Ensembl Gene ENSMUSG00000039672
Encoded Proteins
IDBP-177529
potassium voltage-gated channel, Isk-related subfamily, gene 2
IDBP-252759
potassium voltage-gated channel, Isk-related subfamily, gene 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000159197:
Voltage-gated potassium (Kv) channels represent the most complex class of voltage-gated ion channels from both functional and structural standpoints. Their diverse functions include regulating neurotransmitter release, heart rate, insulin secretion, neuronal excitability, epithelial electrolyte transport, smooth muscle contraction, and cell volume. This gene encodes a member of the potassium channel, voltage-gated, isk-related subfamily. This member is a small integral membrane subunit that assembles with the KCNH2 gene product, a pore-forming protein, to alter its function. This gene is expressed in heart and muscle and the gene mutations are associated with cardiac arrhythmia. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:92292389-92298129
Strand Forward strand
Band C4
Transcripts
ENSMUST00000047383 ENSMUSP00000048849
ENSMUST00000113971 ENSMUSP00000109604
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005242 inward rectifier potassium channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005251 delayed rectifier potassium channel activity
GO:0005515 protein binding
GO:0015459 potassium channel regulator activity
GO:0042803 protein homodimerization activity
GO:0044325 ion channel binding
GO:1902282 voltage-gated potassium channel activity involved in ventricular cardiac muscle cell action potential repolarization
Biological Process
GO:0006811 ion transport
GO:0007568 aging
GO:0010107 potassium ion import
GO:0034613 cellular protein localization
GO:0035690 cellular response to drug
GO:0043586 tongue development
GO:0060306 regulation of membrane repolarization
GO:0060307 regulation of ventricular cardiac muscle cell membrane repolarization
GO:0071435 potassium ion export
GO:0071805 potassium ion transmembrane transport
GO:0086002 cardiac muscle cell action potential involved in contraction
GO:0086005 ventricular cardiac muscle cell action potential
GO:0086009 membrane repolarization
GO:0086011 membrane repolarization during action potential
GO:0086091 regulation of heart rate by cardiac conduction
GO:1901379 regulation of potassium ion transmembrane transport
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:1901979 regulation of inward rectifier potassium channel activity
GO:1902159 regulation of cyclic nucleotide-gated ion channel activity
GO:1902259 regulation of delayed rectifier potassium channel activity
GO:2001257 regulation of cation channel activity
Cellular Component
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0008076 voltage-gated potassium channel complex
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000159197
View Gene Order
ENSBTAG00000026260
Not yet available
Pathways
NETPATH
REACTOME
KEGG
mmu04971
Gastric acid secretion pathway
INOH
PID NCI
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
hsa04971
Gastric acid secretion pathway
INOH
PID NCI
Cross-References
SwissProt Q9D808
TrEMBL
UniProt Splice Variant
Entrez Gene 246133
UniGene Mm.156736 Mm.410006
RefSeq XM_006523033 NM_134110
OMIM
CCDS CCDS28333
HPRD
IMGT
MGI ID MGI:1891123
MGI Symbol Kcne2
EMBL AK008619 BC022699
GenPept AAH22699 BAB25781
RNA Seq Atlas 246133

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca