Version 5.4
Homo sapiens Gene: RIT2
Summary
InnateDB Gene IDBG-2736.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RIT2
Gene Name Ras-like without CAAX 2
Synonyms RIBA; RIN; ROC2
Species Homo sapiens
Ensembl Gene ENSG00000152214
Encoded Proteins
IDBP-2738
Ras-like without CAAX 2
IDBP-726010
IDBP-727247
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RIN belongs to the RAS (HRAS; MIM 190020) superfamily of small GTPases (Shao et al., 1999 [PubMed 10545207]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:42743227-43115691
Strand Reverse strand
Band q12.3
Transcripts
ENST00000326695 ENSP00000321805
ENST00000594852
ENST00000589109 ENSP00000467217
ENST00000590910 ENSP00000466620
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005525 GTP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0007268 synaptic transmission
GO:0015031 protein transport
GO:0048011 neurotrophin TRK receptor signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000057455
View Gene Order
Pathways
NETPATH
REACTOME
REACT_12077
Signalling to p38 via RIT and RIN pathway
REACT_11061
Signalling by NGF pathway
REACT_111102
Signal Transduction pathway
REACT_12058
Signalling to ERKs pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
KEGG
INOH
PID NCI
mapktrkpathway
Trk receptor signaling mediated by the MAPK pathway
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
Cross-References
SwissProt Q99578
TrEMBL K7EMR8
UniProt Splice Variant
Entrez Gene 6014
UniGene Hs.464985
RefSeq NM_001272077 NM_002930
HUGO HGNC:10017
OMIM 609592
CCDS CCDS11921 CCDS62431
HPRD
IMGT
EMBL AC025480 AC091169 AC100779 AF493922 AK313823 AY563951 BC018060 CH471088 U71204 U78164 U78166 Y07565
GenPept AAB42214 AAB64245 AAB64247 AAH18060 AAM12636 AAS75332 BAG36558 CAA68850 EAX01432
RNA Seq Atlas 6014

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca