Version 5.4
Homo sapiens Gene: CNTN1
Summary
InnateDB Gene IDBG-27462.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNTN1
Gene Name contactin 1
Synonyms F3; GP135; MYPCN
Species Homo sapiens
Ensembl Gene ENSG00000018236
Encoded Proteins
IDBP-27466
contactin 1
IDBP-27468
contactin 1
IDBP-592023
contactin 1
IDBP-602129
contactin 1
IDBP-596356
contactin 1
IDBP-596986
contactin 1
IDBP-595819
contactin 1
IDBP-600383
contactin 1
IDBP-587188
contactin 1
IDBP-595943
contactin 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:40692442-41072418
Strand Forward strand
Band q12
Transcripts
ENST00000347616 ENSP00000325660
ENST00000348761 ENSP00000261160
ENST00000550305
ENST00000548481 ENSP00000449517
ENST00000547702 ENSP00000448004
ENST00000551424 ENSP00000450412
ENST00000551295 ENSP00000447006
ENST00000548005 ENSP00000447862
ENST00000552248 ENSP00000447860
ENST00000547849 ENSP00000448653
ENST00000552913 ENSP00000449706
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 15 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
GO:0030246 carbohydrate binding
Biological Process
GO:0007155 cell adhesion
GO:0007219 Notch signaling pathway
GO:0007411 axon guidance
GO:0010628 positive regulation of gene expression
GO:0010765 positive regulation of sodium ion transport
GO:0010976 positive regulation of neuron projection development
GO:0021549 cerebellum development
GO:0031175 neuron projection development
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0031225 anchored component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000055022
View Gene Order
ENSBTAG00000020679
Not yet available
Pathways
NETPATH
NetPath_3
Notch pathway
REACTOME
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_160205
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
REACT_22312
Neurofascin interactions pathway
REACT_22205
L1CAM interactions pathway
REACT_111045
Developmental Biology pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_18266
Axon guidance pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_111102
Signal Transduction pathway
REACT_118721
Signaling by NOTCH2 pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_116125
Disease pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.143434 Hs.605950 Hs.741112
RefSeq NM_001256063 NM_001256064 NM_001843 NM_175038 XM_005268651 XM_006719241
HUGO
OMIM
CCDS CCDS58225 CCDS8737 CCDS8738
HPRD 07189
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca