Version 5.4
Homo sapiens Gene: VIPR1
Summary
InnateDB Gene IDBG-27717.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol VIPR1
Gene Name vasoactive intestinal peptide receptor 1
Synonyms HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG; VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R
Species Homo sapiens
Ensembl Gene ENSG00000114812
Encoded Proteins
IDBP-27719
vasoactive intestinal peptide receptor 1
IDBP-373370
vasoactive intestinal peptide receptor 1
IDBP-373371
vasoactive intestinal peptide receptor 1
IDBP-373375
vasoactive intestinal peptide receptor 1
IDBP-373383
vasoactive intestinal peptide receptor 1
IDBP-373384
vasoactive intestinal peptide receptor 1
IDBP-373386
vasoactive intestinal peptide receptor 1
IDBP-373391
vasoactive intestinal peptide receptor 1
IDBP-373394
vasoactive intestinal peptide receptor 1
IDBP-591567
vasoactive intestinal peptide receptor 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a receptor for vasoactive intestinal peptide, a small neuropeptide. Vasoactive intestinal peptide is involved in smooth muscle relaxation, exocrine and endocrine secretion, and water and ion flux in lung and intestinal epithelia. Its actions are effected through integral membrane receptors associated with a guanine nucleotide binding protein which activates adenylate cyclase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:42489299-42537573
Strand Forward strand
Band p22.1
Transcripts
ENST00000325123 ENSP00000327246
ENST00000433647 ENSP00000394950
ENST00000450274 ENSP00000415013
ENST00000438259 ENSP00000415371
ENST00000443646 ENSP00000388479
ENST00000436487 ENSP00000393215
ENST00000439910 ENSP00000403680
ENST00000439731 ENSP00000403478
ENST00000446673 ENSP00000396204
ENST00000473495
ENST00000490161
ENST00000487545
ENST00000473575
ENST00000495189
ENST00000465338
ENST00000498102
ENST00000543411 ENSP00000445701
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004888 transmembrane signaling receptor activity
GO:0004930 G-protein coupled receptor activity
GO:0004999 vasoactive intestinal polypeptide receptor activity
GO:0005515 protein binding
Biological Process
GO:0006936 muscle contraction
GO:0006955 immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007187 G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268 synaptic transmission
GO:0007586 digestion
GO:0008284 positive regulation of cell proliferation
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032528
View Gene Order
ENSBTAG00000006567
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
reg_gr_pathway
Glucocorticoid receptor regulatory network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.348500 Hs.683175 Hs.739343
RefSeq NM_001251882 NM_001251883 NM_001251884 NM_001251885 NM_004624 XM_005265437 XM_005265438 XM_005265439 XM_005265440 XM_005265441 XM_006713323
HUGO
OMIM
CCDS CCDS2698 CCDS58827 CCDS58828 CCDS58829
HPRD 01890
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca