InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VIPR1

Summary

InnateDB Protein

IDBP-27719.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VIPR1

Protein Name

vasoactive intestinal peptide receptor 1

Synonyms

HVR1; II; PACAP-R-2; PACAP-R2; RDC1; V1RG; VAPC1; VIP-R-1; VIPR; VIRG; VPAC1; VPAC1R; VPCAP1R;

Species

Homo sapiens

Ensembl Protein

ENSP00000327246

InnateDB Gene

IDBG-27717 (VIPR1)

Protein Structure

UniProt Annotation

Function

This is a receptor for VIP. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. The affinity is VIP = PACAP-27 > PACAP-38. {ECO:0000269PubMed:8926282}.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

In lung, HT-29 colonic epithelial cells, Raji B-lymphoblasts. Lesser extent in brain, heart, kidney, liver and placenta. Not expressed in CD4+ or CD8+ T-cells. Expressed in the T-cell lines HARRIS, HuT 78, Jurkat and SUP-T1, but not in the T- cell lines Peer, MOLT-4, HSB and YT. {ECO:0000269PubMed:8926282}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004888	transmembrane signaling receptor activity
GO:0004930	G-protein coupled receptor activity
GO:0004999	vasoactive intestinal polypeptide receptor activity
GO:0005515	protein binding

Biological Process

GO:0006936	muscle contraction
GO:0006955	immune response
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007187	G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
GO:0007268	synaptic transmission
GO:0007586	digestion
GO:0008284	positive regulation of cell proliferation

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043235	receptor complex

Protein Structure and Domains

PDB ID

InterPro

IPR000832 GPCR, family 2, secretin-like
IPR001571 GPCR, family 2, vasoactive intestinal peptide receptor
IPR001771 GPCR, family 2, vasoactive intestinal peptide receptor 1
IPR001879 GPCR, family 2, extracellular hormone receptor domain
IPR017981 GPCR, family 2-like

PFAM

PF00002
PF02793

PRINTS

PR00249
PR00491
PR01154

PIRSF

SMART

SM00008

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt