Version 5.4
Homo sapiens Gene: CNGB3
Summary
InnateDB Gene IDBG-27753.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CNGB3
Gene Name cyclic nucleotide gated channel beta 3
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170289
Encoded Proteins
IDBP-27757
cyclic nucleotide gated channel beta 3
IDBP-478110
cyclic nucleotide gated channel beta 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:86553977-86743675
Strand Reverse strand
Band q21.3
Transcripts
ENST00000320005 ENSP00000316605
ENST00000517327 ENSP00000428329
ENST00000519777
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005222 intracellular cAMP activated cation channel activity
GO:0005223 intracellular cGMP activated cation channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
GO:0030553 cGMP binding
Biological Process
GO:0006810 transport
GO:0006812 cation transport
GO:0007165 signal transduction
GO:0007601 visual perception
GO:0007603 phototransduction, visible light
GO:0042391 regulation of membrane potential
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005887 integral component of plasma membrane
GO:1902495 transmembrane transporter complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000056494
View Gene Order
ENSBTAG00000036304
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
cone_pathway
Visual signal transduction: Cones
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.154433
RefSeq NM_019098 XM_006716593
HUGO
OMIM
CCDS CCDS6244
HPRD 05468
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca