Version 5.4
Mus musculus Gene: Cngb3
Summary
InnateDB Gene IDBG-130960.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Cngb3
Gene Name cyclic nucleotide gated channel beta 3
Synonyms CCNC2; CNG6; Cngbeta2
Species Mus musculus
Ensembl Gene ENSMUSG00000056494
Encoded Proteins
IDBP-130962
cyclic nucleotide gated channel beta 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000170289:
This gene encodes the beta subunit of a cyclic nucleotide-gated ion channel. The encoded beta subunit appears to play a role in modulation of channel function in cone photoreceptors. This heterotetrameric channel is necessary for sensory transduction, and mutations in this gene have been associated with achromatopsia 3, progressive cone dystrophy, and juvenile macular degeneration, also known as Stargardt Disease. [provided by RefSeq, Feb 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:19280850-19510623
Strand Forward strand
Band A3
Transcripts
ENSMUST00000102999 ENSMUSP00000100064
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005222 intracellular cAMP activated cation channel activity
GO:0005223 intracellular cGMP activated cation channel activity
GO:0005249 voltage-gated potassium channel activity
GO:0005515 protein binding
GO:0030553 cGMP binding
Biological Process
GO:0006812 cation transport
GO:0007601 visual perception
GO:0007603 phototransduction, visible light
GO:0009187 cyclic nucleotide metabolic process
GO:0042391 regulation of membrane potential
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:1902495 transmembrane transporter complex
Orthologs
Species
Homo sapiens
Bos taurus
Gene ID
Gene Order
ENSG00000170289
View Gene Order
ENSBTAG00000036304
Not yet available
Pathway Predictions based on Human Orthology Data
NETPATH
REACTOME
KEGG
INOH
PID NCI
cone_pathway
Visual signal transduction: Cones
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.408598 Mm.445778
RefSeq NM_013927 XM_006537979
OMIM
CCDS CCDS17990
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca