InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CDKN2D

Summary

InnateDB Gene

IDBG-27803.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKN2D

Gene Name

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

Synonyms

INK4D; p19; p19-INK4D

Species

Homo sapiens

Ensembl Gene

ENSG00000129355

Encoded Proteins

IDBP-27805

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

IDBP-243300

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the INK4 family of cyclin-dependent kinase inhibitors. This protein has been shown to form a stable complex with CDK4 or CDK6, and prevent the activation of the CDK kinases, thus function as a cell growth regulator that controls cell cycle G1 progression. The abundance of the transcript of this gene was found to oscillate in a cell-cycle dependent manner with the lowest expression at mid G1 and a maximal expression during S phase. The negative regulation of the cell cycle involved in this protein was shown to participate in repressing neuronal proliferation, as well as spermatogenesis. Two alternatively spliced variants of this gene, which encode an identical protein, have been reported. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:10566462-10569059

Strand

Reverse strand

Band

p13.2

Transcripts

ENST00000335766	ENSP00000337056
ENST00000393599	ENSP00000377224

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	12 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0000731	DNA synthesis involved in DNA repair
GO:0007050	cell cycle arrest
GO:0007605	sensory perception of sound
GO:0008285	negative regulation of cell proliferation
GO:0009411	response to UV
GO:0030308	negative regulation of cell growth
GO:0032526	response to retinoic acid
GO:0033280	response to vitamin D
GO:0042326	negative regulation of phosphorylation
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048102	autophagic cell death
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage