InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CDKN2D

Summary

InnateDB Protein

IDBP-27805.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CDKN2D

Protein Name

cyclin-dependent kinase inhibitor 2D (p19, inhibits CDK4)

Synonyms

INK4D; p19; p19-INK4D;

Species

Homo sapiens

Ensembl Protein

ENSP00000337056

InnateDB Gene

IDBG-27803 (CDKN2D)

Protein Structure

UniProt Annotation

Function

Interacts strongly with CDK4 and CDK6 and inhibits them. {ECO:0000269PubMed:7739548, ECO:0000269PubMed:8741839}.

Subcellular Localization

Nucleus {ECO:0000269PubMed:9482106}. Cytoplasm {ECO:0000269PubMed:9482106}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004861	cyclin-dependent protein serine/threonine kinase inhibitor activity
GO:0005515	protein binding
GO:0019901	protein kinase binding

Biological Process

GO:0000079	regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0000731	DNA synthesis involved in DNA repair
GO:0007050	cell cycle arrest
GO:0008285	negative regulation of cell proliferation
GO:0009411	response to UV
GO:0030308	negative regulation of cell growth
GO:0032526	response to retinoic acid
GO:0033280	response to vitamin D
GO:0042326	negative regulation of phosphorylation
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0048102	autophagic cell death
GO:0071901	negative regulation of protein serine/threonine kinase activity
GO:1902230	negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage