Version 5.4
Homo sapiens Gene: ZCRB1
Summary
InnateDB Gene IDBG-27826.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ZCRB1
Gene Name zinc finger CCHC-type and RNA binding motif 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000139168
Encoded Proteins
IDBP-27828
zinc finger CCHC-type and RNA binding motif 1
IDBP-595332
zinc finger CCHC-type and RNA binding motif 1
IDBP-599670
zinc finger CCHC-type and RNA binding motif 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Pre-mRNA splicing is catalyzed by the spliceosome. U12-type spliceosome binds U12-type pre-mRNAs and recognizes the 5' splice site and branch-point sequence. U11 and U12 snRNPs are components of U12-type spliceosome and function as a molecular bridge connecting both ends of the intron. The protein encoded by this gene contains a RNA recognition motif. It was identified as one of the protein components of U11/U12 snRNPs. This protein and many other U11/U12 snRNP proteins are highly conserved in organisms known to contain U12-type introns. These proteins have been shown to be essential for cell viability, suggesting the key roles in U12-type splicing. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:42312078-42326118
Strand Reverse strand
Band q12
Transcripts
ENST00000266529 ENSP00000266529
ENST00000552673 ENSP00000446732
ENST00000552235 ENSP00000448780
ENST00000548022
ENST00000551102
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006397 mRNA processing
GO:0008380 RNA splicing
Cellular Component
GO:0005654 nucleoplasm
GO:0005689 U12-type spliceosomal complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022635
View Gene Order
ENSBTAG00000019119
Not yet available
Cross-References
SwissProt Q8TBF4
TrEMBL A0A024R106 F8VXY6 G3V1V1 Q05DR1
UniProt Splice Variant
Entrez Gene 85437
UniGene Hs.496279 Hs.622043
RefSeq NM_033114
HUGO HGNC:29620
OMIM 610750
CCDS CCDS8740
HPRD
IMGT
EMBL AB062361 AC079684 BC005099 BC010177 BC022543 BK005200 CH471111
GenPept AAH05099 AAH10177 AAH22543 BAB56132 DAA05498 EAW57842 EAW57843 EAW57844
RNA Seq Atlas 85437

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca