Version 5.4
Homo sapiens Gene: PDE8A
Summary
InnateDB Gene IDBG-27887.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PDE8A
Gene Name phosphodiesterase 8A
Synonyms HsT19550
Species Homo sapiens
Ensembl Gene ENSG00000073417
Encoded Proteins
IDBP-27889
phosphodiesterase 8A
IDBP-27891
phosphodiesterase 8A
IDBP-241320
phosphodiesterase 8A
IDBP-596806
phosphodiesterase 8A
IDBP-600583
phosphodiesterase 8A
IDBP-595828
phosphodiesterase 8A
IDBP-597643
phosphodiesterase 8A
IDBP-585178
phosphodiesterase 8A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase (PDE) family, and PDE8 subfamily. This PDE hydrolyzes the second messenger, cAMP, which is a regulator and mediator of a number of cellular responses to extracellular signals. Thus, by regulating the cellular concentration of cAMP, this protein plays a key role in many important physiological processes. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:84980440-85139145
Strand Forward strand
Band q25.3
Transcripts
ENST00000310298 ENSP00000311453
ENST00000339708 ENSP00000340679
ENST00000394553 ENSP00000378056
ENST00000478717 ENSP00000432309
ENST00000485596 ENSP00000431976
ENST00000557957 ENSP00000453808
ENST00000559742 ENSP00000452907
ENST00000559086 ENSP00000454094
ENST00000560789
ENST00000557819
ENST00000558543
ENST00000557954
ENST00000561105
ENST00000561374
ENST00000560333
ENST00000561024
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000156 two-component response regulator activity
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity
GO:0004871 signal transducer activity
GO:0046872 metal ion binding
Biological Process
GO:0000160 phosphorelay signal transduction system
GO:0006198 cAMP catabolic process
GO:0006355 regulation of transcription, DNA-templated
GO:0007165 signal transduction
GO:0009187 cyclic nucleotide metabolic process
GO:0035556 intracellular signal transduction
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025584
View Gene Order
ENSBTAG00000015909
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.9333
RefSeq NM_001243137 NM_002605 NM_173454 XM_005254933
HUGO
OMIM
CCDS CCDS10336 CCDS10337 CCDS58397
HPRD 09114
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca