InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PDE8A

Summary

InnateDB Protein

IDBP-595828.2

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PDE8A

Protein Name

phosphodiesterase 8A

Synonyms

HsT19550;

Species

Homo sapiens

Ensembl Protein

ENSP00000453808

InnateDB Gene

IDBG-27887 (PDE8A)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.

Experimentally validated
Total	9 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000156	two-component response regulator activity
GO:0004114	3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004871	signal transducer activity
GO:0046872	metal ion binding

Biological Process

GO:0000160	phosphorelay signal transduction system
GO:0006198	cAMP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0007165	signal transduction
GO:0009187	cyclic nucleotide metabolic process
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005829	cytosol
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

InterPro

IPR000014 PAS domain
IPR001789 Signal transduction response regulator, receiver domain
IPR002073 3\'5\'-cyclic nucleotide phosphodiesterase, catalytic domain
IPR003607 HD/PDEase domain
IPR011006 CheY-like superfamily
IPR013656 PAS fold-4
IPR013767 PAS fold
IPR023088 3\'5\'-cyclic nucleotide phosphodiesterase

PFAM

PF13188
PF13426
PF00072
PF00233
PF08448
PF00989

PRINTS

PR00387

PIRSF

SMART

SM00091
SM00448
SM00471

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt