Version 5.4
Homo sapiens Gene: TRIM22
Summary
InnateDB Gene IDBG-27924.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM22
Gene Name tripartite motif containing 22
Synonyms GPSTAF50; RNF94; STAF50
Species Homo sapiens
Ensembl Gene ENSG00000132274
Encoded Proteins
IDBP-27926
tripartite motif containing 22
IDBP-364369
tripartite motif containing 22
IDBP-364373
tripartite motif containing 22
IDBP-364377
tripartite motif containing 22
IDBP-364386
tripartite motif containing 22
IDBP-364387
tripartite motif containing 22
IDBP-364388
tripartite motif containing 22
IDBP-364389
tripartite motif containing 22
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 19218198
An E3 ubiquitin ligase that ubiquitinates the viral 3C protease and acts as a component of an antiviral pathway induced by IFN against picornaviruses
Entrez Gene
Summary The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon's antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein down-regulates transcription from the HIV-1 LTR promoter region, suggesting that function of this protein may be to mediate interferon\'s antiviral effects. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:5689689-5737089
Strand Forward strand
Band p15.4
Transcripts
ENST00000379965 ENSP00000369299
ENST00000425490 ENSP00000400417
ENST00000454828 ENSP00000393250
ENST00000414641 ENSP00000396849
ENST00000414897 ENSP00000388994
ENST00000450670 ENSP00000406412
ENST00000429063 ENSP00000409991
ENST00000444844 ENSP00000404204
ENST00000460454
ENST00000480395
ENST00000493494
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003714 transcription corepressor activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006955 immune response
GO:0009615 response to virus
GO:0016032 viral process
GO:0016567 protein ubiquitination
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087 innate immune response (InnateDB)
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051607 defense response to virus
GO:0070206 protein trimerization
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0015030 Cajal body
GO:0016607 nuclear speck
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 10346
UniGene Hs.501778 Hs.660856
RefSeq NM_001199573 NM_006074
HUGO HGNC:16379
OMIM 606559
CCDS CCDS41612
HPRD 05951
IMGT
EMBL
GenPept
RNA Seq Atlas 10346

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca