InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: TRIM22

Summary

InnateDB Protein

IDBP-27926.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TRIM22

Protein Name

tripartite motif containing 22

Synonyms

GPSTAF50; RNF94; STAF50;

Species

Homo sapiens

Ensembl Protein

ENSP00000369299

InnateDB Gene

IDBG-27924 (TRIM22)

Protein Structure

UniProt Annotation

Function

Interferon-induced antiviral protein involved in cell innate immunity. The antiviral activity could in part be mediated by TRIM22-dependent ubiquitination of viral proteins. Plays a role in restricting the replication of HIV-1, encephalomyocarditis virus (EMCV) and hepatitis B virus (HBV). Acts as a transcriptional repressor of HBV core promoter. May have E3 ubiquitin-protein ligase activity. {ECO:0000269PubMed:18389079, ECO:0000269PubMed:18656448, ECO:0000269PubMed:19218198, ECO:0000269PubMed:19585648}.

Subcellular Localization

Cytoplasm. Nucleus. Nucleus speckle. Nucleus, Cajal body. Note=Localizes predominanltly into the nucleus, found in cytoplasm to some extent. Forms distinct nuclear bodies that undergo dynamic changes during cell cycle progression. Nuclear bodies start to form in the early G0/G1 phase but become speckle-like in the S-phase and completely dispersed in mitosis. 35% of TRIM22 nuclear bodies overlap or are found adjacent to Cajal bodies.

Disease Associations

Tissue Specificity

Strongly expressed in peripheral blood leukocytes, spleen, thymus, and ovary. Expressed at basal levels in other tissues. {ECO:0000269PubMed:7797467}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003714	transcription corepressor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0046872	metal ion binding

Biological Process

GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006955	immune response
GO:0009615	response to virus
GO:0016032	viral process
GO:0016567	protein ubiquitination
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051607	defense response to virus
GO:0070206	protein trimerization

Cellular Component

GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0015030	Cajal body
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

InterPro

IPR000315 Zinc finger, B-box
IPR001841 Zinc finger, RING-type
IPR001870 B30.2/SPRY domain
IPR003877 SPRY domain
IPR003879 Butyrophylin-like
IPR008985 Concanavalin A-like lectin/glucanases superfamily
IPR018957 Zinc finger, C3HC4 RING-type

PFAM

PF00643
PF13639
PF14634
PF00622
PF00097

PRINTS

PR01407

PIRSF

SMART

SM00336
SM00184
SM00449

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt