Version 5.4
Homo sapiens Gene: CLIC6
Summary
InnateDB Gene IDBG-2804.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIC6
Gene Name chloride intracellular channel 6
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159212
Encoded Proteins
IDBP-2806
chloride intracellular channel 6
IDBP-2808
chloride intracellular channel 6
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the chloride intracellular channel family of proteins. The gene is part of a large triplicated region found on chromosomes 1, 6, and 21. An alternatively spliced transcript variant has been described, but its biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:34669389-34718227
Strand Forward strand
Band q22.12
Transcripts
ENST00000360731 ENSP00000353959
ENST00000349499 ENSP00000290332
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005247 voltage-gated chloride channel activity
GO:0008022 protein C-terminus binding
GO:0031749 D2 dopamine receptor binding
GO:0031750 D3 dopamine receptor binding
GO:0031751 D4 dopamine receptor binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006821 chloride transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022949
View Gene Order
ENSBTAG00000001753
Not yet available
Cross-References
SwissProt Q96NY7
TrEMBL
UniProt Splice Variant
Entrez Gene 54102
UniGene Hs.473695 Hs.713951
RefSeq NM_053277
HUGO HGNC:2065
OMIM 615321
CCDS CCDS13638
HPRD
IMGT
EMBL AF426169 AF448438 AF448439 AK092733 AK289663 AP001720 BC040196 CH471079
GenPept AAH40196 AAL24813 AAN76729 AAN76730 BAC03959 BAF82352 EAX09775
RNA Seq Atlas 54102

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca