Homo sapiens Protein: CLIC6
Summary
InnateDB Protein IDBP-2806.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CLIC6
Protein Name chloride intracellular channel 6
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000353959
InnateDB Gene IDBG-2804 (CLIC6)
Protein Structure
UniProt Annotation
Function May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Cell membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}. Note=Predominantly cytoplasmic. Upon chloride ion efflux from the cell, it is translocated to the plasma membrane (By similarity). {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed in brain, placenta, pancreas and liver. {ECO:0000269PubMed:12226712}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005247 voltage-gated chloride channel activity
Biological Process
GO:0006821 chloride transport
GO:0034765 regulation of ion transmembrane transport
GO:0044070 regulation of anion transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0034707 chloride channel complex
GO:0070062 extracellular vesicular exosome
Protein Structure and Domains
PDB ID
InterPro IPR002946 Intracellular chloride channel
IPR010987 Glutathione S-transferase, C-terminal-like
IPR012336 Thioredoxin-like fold
PFAM PF13098
PF13192
PF13462
PF13905
PRINTS PR01263
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96NY7
PhosphoSite PhosphoSite-Q96NY7
TrEMBL
UniProt Splice Variant
Entrez Gene 54102
UniGene Hs.713951
RefSeq
HUGO HGNC:2065
OMIM 615321
CCDS
HPRD
IMGT
EMBL AF426169 AF448438 AF448439 AK092733 AK289663 AP001720 BC040196 CH471079
GenPept AAH40196 AAL24813 AAN76729 AAN76730 BAC03959 BAF82352 EAX09775