InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ITGAM

Summary

InnateDB Gene

IDBG-28139.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ITGAM

Gene Name

integrin, alpha M (complement component 3 receptor 3 subunit)

Synonyms

CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6

Species

Homo sapiens

Ensembl Gene

ENSG00000169896

Encoded Proteins

IDBP-28141

integrin, alpha M (complement component 3 receptor 3 subunit)

IDBP-588493

integrin, alpha M (complement component 3 receptor 3 subunit)

IDBP-745522

IDBP-751888

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20639876

ITGAM (CD11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the MYD88 and TICAM1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.

PMID 21245270

ITGAM :: ITGB2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by ITGAM :: ITGB2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection. (Demonstrated in murine model)

InnateDB Annotation from Orthologs

Summary

PMID 20639876

[Mus musculus] Itgam (Cd11b integrin) is activated via Toll-like receptors (TLRs) and engages in crosstalk with the Myd88 and Ticam1 (TRIF) pathways inhibiting TLR signalling in innate immune responses.

PMID 21245270

[Mus musculus] Itgam :: Itgb2 is the principal leukocyte receptor involved in the recognition of the fungus Candida albicans. Recognition of Pra1p protein of C. albicans by Itgam :: Itgb2 plays a pivotal role in determining fungal virulence, and host response/protection against C. albicans infection.

PMID 24423728

[Mus musculus] Itgam (Cd11b) fine tunes the balance between adaptive and innate immune responses initiated by LPS by modulating the trafficking and signalling functions of Tlr4 in a cell-type-specific manner.

PMID 25538234

[Mus musculus] Ptpn11 phosphatase function positively regulates Clec7a- and Itgam-stimulated reactive oxygen species production in macrophages by dephosphorylating and thus mitigating the inhibitory function of Sirpa and by promoting Mapk1/Mapk3 activation.

Entrez Gene

Summary

This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 (\'Mac-1\'), or inactivated-C3b (iC3b) receptor 3 (\'CR3\'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:31259990-31332892

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000287497	ENSP00000287497
ENST00000544665	ENSP00000441691
ENST00000570242
ENST00000567031	ENSP00000454568
ENST00000565142	ENSP00000461850
ENST00000561838
ENST00000569746
ENST00000567178

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	21 [view]
Protein-DNA	6 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001846	opsonin binding
GO:0001948	glycoprotein binding
GO:0005515	protein binding
GO:0008201	heparin binding
GO:0043395	heparan sulfate proteoglycan binding
GO:0046872	metal ion binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0002224	toll-like receptor signaling pathway
GO:0002523	leukocyte migration involved in inflammatory response
GO:0007155	cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007229	integrin-mediated signaling pathway
GO:0007596	blood coagulation
GO:0014005	microglia development
GO:0016337	single organismal cell-cell adhesion
GO:0030198	extracellular matrix organization
GO:0030593	neutrophil chemotaxis
GO:0034142	toll-like receptor 4 signaling pathway
GO:0045087	innate immune response (InnateDB)
GO:0045123	cellular extravasation
GO:0050798	activated T cell proliferation
GO:0050900	leukocyte migration

Cellular Component

GO:0005634	nucleus
GO:0005886	plasma membrane
GO:0008305	integrin complex
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016021	integral component of membrane
GO:0070062	extracellular vesicular exosome