InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: VAMP2

Summary

InnateDB Gene

IDBG-281536.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAMP2

Gene Name

vesicle-associated membrane protein 2 (synaptobrevin 2)

Synonyms

SYB2; VAMP-2

Species

Homo sapiens

Ensembl Gene

ENSG00000220205

Encoded Proteins

IDBP-28075

vesicle-associated membrane protein 2 (synaptobrevin 2)

IDBP-759599

IDBP-475613

vesicle-associated membrane protein 2 (synaptobrevin 2)

IDBP-763334

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the vesicle-associated membrane protein (VAMP)/synaptobrevin family. Synaptobrevins/VAMPs, syntaxins, and the 25-kD synaptosomal-associated protein SNAP25 are the main components of a protein complex involved in the docking and/or fusion of synaptic vesicles with the presynaptic membrane. This gene is thought to participate in neurotransmitter release at a step between docking and fusion. The protein forms a stable complex with syntaxin, synaptosomal-associated protein, 25 kD, and synaptotagmin. It also forms a distinct complex with synaptophysin. It is a likely candidate gene for familial infantile myasthenia (FIMG) because of its map location and because it encodes a synaptic vesicle protein of the type that has been implicated in the pathogenesis of FIMG. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:8159149-8163546

Strand

Reverse strand

Band

p13.1

Transcripts

ENST00000316509	ENSP00000314214
ENST00000404970	ENSP00000466995
ENST00000488857	ENSP00000418572
ENST00000481878	ENSP00000467399

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.

Experimentally validated
Total	73 [view]
Protein-Protein	71 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005543	phospholipid binding
GO:0008022	protein C-terminus binding
GO:0017022	myosin binding
GO:0017075	syntaxin-1 binding
GO:0019905	syntaxin binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006461	protein complex assembly
GO:0006892	post-Golgi vesicle-mediated transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0009749	response to glucose
GO:0014047	glutamate secretion
GO:0015031	protein transport
GO:0016079	synaptic vesicle exocytosis
GO:0016192	vesicle-mediated transport
GO:0017156	calcium ion-dependent exocytosis
GO:0017157	regulation of exocytosis
GO:0032869	cellular response to insulin stimulus
GO:0043001	Golgi to plasma membrane protein transport
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0060291	long-term synaptic potentiation
GO:0060627	regulation of vesicle-mediated transport
GO:0061024	membrane organization
GO:0061025	membrane fusion
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030136	clathrin-coated vesicle
GO:0030141	secretory granule
GO:0030666	endocytic vesicle membrane
GO:0030667	secretory granule membrane
GO:0030672	synaptic vesicle membrane
GO:0031201	SNARE complex
GO:0031410	cytoplasmic vesicle
GO:0042589	zymogen granule membrane
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0043231	intracellular membrane-bounded organelle
GO:0044306	neuron projection terminus
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0060203	clathrin-sculpted glutamate transport vesicle membrane
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex
GO:0070062	extracellular vesicular exosome
GO:0070083	clathrin-sculpted monoamine transport vesicle membrane