InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: VAMP2

Summary

InnateDB Protein

IDBP-28075.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

VAMP2

Protein Name

vesicle-associated membrane protein 2 (synaptobrevin 2)

Synonyms

SYB2; VAMP-2;

Species

Homo sapiens

Ensembl Protein

ENSP00000314214

InnateDB Gene

IDBG-281536 (VAMP2)

Protein Structure

UniProt Annotation

Function

Involved in the targeting and/or fusion of transport vesicles to their target membrane.

Subcellular Localization

Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane; Single-pass type IV membrane protein. Cell junction, synapse, synaptosome. Note=Neuronal synaptic vesicles.

Disease Associations

Tissue Specificity

Nervous system and skeletal muscle. {ECO:0000269PubMed:8760387}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.

Experimentally validated
Total	73 [view]
Protein-Protein	71 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005543	phospholipid binding
GO:0008022	protein C-terminus binding
GO:0017022	myosin binding
GO:0017075	syntaxin-1 binding
GO:0019905	syntaxin binding
GO:0032403	protein complex binding
GO:0042802	identical protein binding

Biological Process

GO:0006112	energy reserve metabolic process
GO:0006461	protein complex assembly
GO:0006892	post-Golgi vesicle-mediated transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0009749	response to glucose
GO:0014047	glutamate secretion
GO:0015031	protein transport
GO:0016079	synaptic vesicle exocytosis
GO:0016192	vesicle-mediated transport
GO:0017156	calcium ion-dependent exocytosis
GO:0017157	regulation of exocytosis
GO:0032869	cellular response to insulin stimulus
GO:0043001	Golgi to plasma membrane protein transport
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0050796	regulation of insulin secretion
GO:0060291	long-term synaptic potentiation
GO:0060627	regulation of vesicle-mediated transport
GO:0061024	membrane organization
GO:0061025	membrane fusion
GO:0090316	positive regulation of intracellular protein transport

Cellular Component

GO:0005802	trans-Golgi network
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030136	clathrin-coated vesicle
GO:0030141	secretory granule
GO:0030666	endocytic vesicle membrane
GO:0030667	secretory granule membrane
GO:0030672	synaptic vesicle membrane
GO:0031201	SNARE complex
GO:0031410	cytoplasmic vesicle
GO:0042589	zymogen granule membrane
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0043231	intracellular membrane-bounded organelle
GO:0044306	neuron projection terminus
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0060203	clathrin-sculpted glutamate transport vesicle membrane
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070032	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex
GO:0070033	synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II complex
GO:0070044	synaptobrevin 2-SNAP-25-syntaxin-1a complex
GO:0070062	extracellular vesicular exosome
GO:0070083	clathrin-sculpted monoamine transport vesicle membrane