Version 5.4
| Homo sapiens Gene: CEBPD | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-281563.5 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CEBPD | ||||||||||||||||||
| Gene Name | CCAAT/enhancer binding protein (C/EBP), delta | ||||||||||||||||||
| Synonyms | C/EBP-delta; CELF; CRP3; NF-IL6-beta | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000221869 | ||||||||||||||||||
| Encoded Proteins |
CCAAT/enhancer binding protein (C/EBP), delta
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| Protein Structure |
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| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| InnateDB Annotation | |||||||||||||||||||
| Summary |
CEBPD is involved in TLR8 mediated innate immune response by binding to C/EBP cis-acting elements within the TLR8 promoter increasing its transcriptional activity.
CEBPD is a member of the CCAAT enhancer binding protein family and is a transcriptional factor regulating genes in innate immunity and inflammation. The activities of CEBP are regulated via methylation of arginine and lysine side chains.
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| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this intronless gene is a bZIP transcription factor which can bind as a homodimer to certain DNA regulatory regions. It can also form heterodimers with the related protein CEBP-alpha. The encoded protein is important in the regulation of genes involved in immune and inflammatory responses, and may be involved in the regulation of genes associated with activation and/or differentiation of macrophages. The cytogenetic location of this locus has been reported as both 8p11 and 8q11. [provided by RefSeq, Sep 2010] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 8:47736909-47739086 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q11.21 | ||||||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
| No orthologs found for this gene | |||||||||||||||||||
| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
Transcriptional regulation of white adipocyte differentiation pathway
Developmental Biology pathway
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| KEGG | |||||||||||||||||||
| INOH | |||||||||||||||||||
| PID NCI |
Validated targets of C-MYC transcriptional repression
Validated transcriptional targets of deltaNp63 isoforms
IL6-mediated signaling events
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| Cross-References | |||||||||||||||||||
| SwissProt | P49716 | ||||||||||||||||||
| TrEMBL | |||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 1052 | ||||||||||||||||||
| UniGene | Hs.741546 | ||||||||||||||||||
| RefSeq | NM_005195 | ||||||||||||||||||
| HUGO | HGNC:1835 | ||||||||||||||||||
| OMIM | 116898 | ||||||||||||||||||
| CCDS | CCDS6142 | ||||||||||||||||||
| HPRD | 00297 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | BC105109 CH471068 M83667 S63168 | ||||||||||||||||||
| GenPept | AAA59927 AAB27293 AAI05110 EAW86679 | ||||||||||||||||||
| RNA Seq Atlas | 1052 | ||||||||||||||||||