InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CEBPD

Summary

InnateDB Protein

IDBP-293990.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CEBPD

Protein Name

CCAAT/enhancer binding protein (C/EBP), delta

Synonyms

C/EBP-delta; CELF; CRP3; NF-IL6-beta;

Species

Homo sapiens

Ensembl Protein

ENSP00000386165

InnateDB Gene

IDBG-281563 (CEBPD)

Protein Structure

UniProt Annotation

Function

C/EBP is a DNA-binding protein that recognizes two different motifs: the CCAAT homology common to many promoters and the enhanced core homology common to many enhancers. Important transcriptional activator in the regulation of genes involved in immune and inflammatory responses, may play an important role in the regulation of the several genes associated with activation and/or differentiation of macrophages.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 129 experimentally validated interaction(s) in this database.

Experimentally validated
Total	129 [view]
Protein-Protein	42 [view]
Protein-DNA	86 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000978	RNA polymerase II core promoter proximal region sequence-specific DNA binding
GO:0001077	RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter