InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DNM2

Summary

InnateDB Gene

IDBG-28168.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DNM2

Gene Name

dynamin 2

Synonyms

CMT2M; CMTDI1; CMTDIB; DI-CMTB; DYN2; DYNII; LCCS5

Species

Homo sapiens

Ensembl Gene

ENSG00000079805

Encoded Proteins

IDBP-28174

dynamin 2

IDBP-28178

dynamin 2

IDBP-28180

dynamin 2

IDBP-294719

dynamin 2

IDBP-762089

IDBP-761386

IDBP-763531

IDBP-764159

IDBP-765412

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:10718079-10833488

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000355667	ENSP00000347890
ENST00000359692	ENSP00000352721
ENST00000389253	ENSP00000373905
ENST00000408974	ENSP00000386192
ENST00000591819
ENST00000587991
ENST00000587329
ENST00000588976
ENST00000591118
ENST00000591266
ENST00000586939	ENSP00000467430
ENST00000587485
ENST00000590787
ENST00000590806
ENST00000593220
ENST00000593203
ENST00000585892	ENSP00000468734
ENST00000591818	ENSP00000466621
ENST00000589106	ENSP00000466914
ENST00000591701
ENST00000586130
ENST00000587830	ENSP00000466603

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	116 [view]
Protein-Protein	116 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding
GO:0008017	microtubule binding
GO:0019899	enzyme binding

Biological Process

GO:0000086	G2/M transition of mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006892	post-Golgi vesicle-mediated transport
GO:0006897	endocytosis
GO:0007165	signal transduction
GO:0008219	cell death
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031623	receptor internalization
GO:0033572	transferrin transport
GO:0043065	positive regulation of apoptotic process
GO:0044281	small molecule metabolic process
GO:0045893	positive regulation of transcription, DNA-templated
GO:0046209	nitric oxide metabolic process
GO:0048489	synaptic vesicle transport
GO:0050999	regulation of nitric-oxide synthase activity
GO:0061024	membrane organization

Cellular Component

GO:0000139	Golgi membrane
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005874	microtubule
GO:0005886	plasma membrane
GO:0014069	postsynaptic density
GO:0030054	cell junction
GO:0030496	midbody
GO:0030666	endocytic vesicle membrane
GO:0045211	postsynaptic membrane
GO:0070062	extracellular vesicular exosome