Version 5.4
Homo sapiens Gene: SIGLEC15
Summary
InnateDB Gene IDBG-2836.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGLEC15
Gene Name sialic acid binding Ig-like lectin 15
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000197046
Encoded Proteins
IDBP-2842
sialic acid binding Ig-like lectin 15
IDBP-583343
sialic acid binding Ig-like lectin 15
IDBP-727102
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21208791
SIGLEC15 is a member of the SIGLEC protein family that recognize sialoside-based patterns and plays a role in the attenuation of innate immunity to avoid autoimmune destruction.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 18:45825512-45844080
Strand Forward strand
Band q12.3
Transcripts
ENST00000389474 ENSP00000374125
ENST00000546268 ENSP00000443509
ENST00000602118
ENST00000593178
ENST00000587418 ENSP00000466774
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0032956 regulation of actin cytoskeleton organization
GO:0045087 innate immune response (InnateDB)
GO:0045124 regulation of bone resorption
GO:0071402 cellular response to lipoprotein particle stimulus
GO:2001204 regulation of osteoclast development
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000091055
View Gene Order
ENSBTAG00000016620
Not yet available
Pathways
NETPATH
REACTOME
REACT_147694
DAP12 interactions pathway
REACT_6802
Innate Immune System pathway
REACT_6900
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.287692
RefSeq NM_213602 XM_005258249
HUGO
OMIM
CCDS CCDS32819
HPRD 13011
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca