Version 5.4
Homo sapiens Protein: SIGLEC15
Summary
InnateDB Protein IDBP-2842.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SIGLEC15
Protein Name sialic acid binding Ig-like lectin 15
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000374125
InnateDB Gene IDBG-2836 (SIGLEC15)
Protein Structure
UniProt Annotation
Function Binds sialylated glycoproteins. {ECO:0000269PubMed:17483134}.
Subcellular Localization Membrane; Single-pass type I membrane protein.
Disease Associations
Tissue Specificity Expressed in macrophage and/or dendritic cells of spleen and lymph nodes.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0032956 regulation of actin cytoskeleton organization
GO:0045087 innate immune response (InnateDB)
GO:0045124 regulation of bone resorption
GO:0071402 cellular response to lipoprotein particle stimulus
GO:2001204 regulation of osteoclast development
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0043234 protein complex
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
PFAM PF07686
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6ZMC9
PhosphoSite PhosphoSite-Q6ZMC9
TrEMBL
UniProt Splice Variant
Entrez Gene 284266
UniGene Hs.287692
RefSeq NP_998767
HUGO HGNC:27596
OMIM
CCDS CCDS32819
HPRD 13011
IMGT
EMBL AK172835 AK290400 AK290402 CH471088
GenPept BAD18800 BAF83089 BAF83091 EAX01463

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca