InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: BAIAP2L1

Summary

InnateDB Gene

IDBG-28552.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAIAP2L1

Gene Name

BAI1-associated protein 2-like 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000006453

Encoded Proteins

IDBP-28554

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 26348439

[Mus musculus] Baiap2l1 recruits Ube2i to sumoylate Pcbp2, which causes its cytoplasmic translocation during viral infection and the sumoylated Pcbp2 associates with Mavs to initiate its degradation, leading to downregulation of antiviral responses.

Entrez Gene

Summary

This gene encodes a member of the IMD (IRSp53/MIM homology domain) family. Members of this family can be subdivided in two groups, the IRSp53-like and MIM-like, based on the presence or absence of the SH3 (Src homology 3) domain. The protein encoded by this gene contains a conserved IMD, also known as F-actin bundling domain, at the N-terminus, and a canonical SH3 domain near the C-terminus, so it belongs to the IRSp53-like group. This protein is the substrate for insulin receptor tyrosine kinase and binds to the small GTPase Rac. It is involved in signal transduction pathways that link deformation of the plasma membrane and remodeling of the actin cytoskeleton. It also promotes actin assembly and membrane protrusions when overexpressed in mammalian cells, and is essential to the formation of a potent actin assembly complex during EHEC (Enterohemorrhagic Escherichia coli) pedestal formation. [provided by RefSeq, Oct 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:98291651-98401068

Strand

Reverse strand

Band

q22.1

Transcripts

ENST00000005260	ENSP00000005260
ENST00000480580
ENST00000462558
ENST00000473569
ENST00000479789

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding
GO:0070064	proline-rich region binding

Biological Process

GO:0007009	plasma membrane organization
GO:0007165	signal transduction
GO:0009617	response to bacterium
GO:0030838	positive regulation of actin filament polymerization
GO:0046847	filopodium assembly
GO:2000251	positive regulation of actin cytoskeleton reorganization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0015629	actin cytoskeleton
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000038859

View Gene Order

ENSBTAG00000019181

Not yet available

Pathways

NETPATH

NetPath_4

EGFR1 pathway

REACTOME

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.656063 Hs.701668

RefSeq

NM_018842

HUGO

OMIM

CCDS

CCDS34687

HPRD

11270

IMGT

EMBL

GenPept

RNA Seq Atlas