InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: BAIAP2L1

Summary

InnateDB Protein

IDBP-28554.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

BAIAP2L1

Protein Name

Brain-specific angiogenesis inhibitor 1-associated protein 2-like protein 1

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000005260

InnateDB Gene

IDBG-28552 (BAIAP2L1)

Protein Structure

UniProt Annotation

Function

May function as adapter protein. Involved in the formation of clusters of actin bundles. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. {ECO:0000269PubMed:17430976, ECO:0000269PubMed:19366662, ECO:0000269PubMed:22921828}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000269PubMed:19366662}. Note=Recruited to actin pedestals that are formed upon infection by bacteria at bacterial attachment sites.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.

Experimentally validated
Total	22 [view]
Protein-Protein	22 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0008093	cytoskeletal adaptor activity
GO:0017124	SH3 domain binding
GO:0070064	proline-rich region binding

Biological Process

GO:0007009	plasma membrane organization
GO:0007165	signal transduction
GO:0009617	response to bacterium
GO:0030838	positive regulation of actin filament polymerization
GO:0046847	filopodium assembly
GO:2000251	positive regulation of actin cytoskeleton reorganization