InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CCKBR

Summary

InnateDB Gene

IDBG-28586.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCKBR

Gene Name

cholecystokinin B receptor

Synonyms

CCK-B; CCK2R; GASR

Species

Homo sapiens

Ensembl Gene

ENSG00000110148

Encoded Proteins

IDBP-28588

cholecystokinin B receptor

IDBP-589796

cholecystokinin B receptor

IDBP-592640

cholecystokinin B receptor

IDBP-586544

cholecystokinin B receptor

IDBP-603470

cholecystokinin B receptor

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a G-protein coupled receptor for gastrin and cholecystokinin (CCK), regulatory peptides of the brain and gastrointestinal tract. This protein is a type B gastrin receptor, which has a high affinity for both sulfated and nonsulfated CCK analogs and is found principally in the central nervous system and the gastrointestinal tract. A misspliced transcript variant including an intron has been observed in cells from colorectal and pancreatic tumors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:6259736-6272127

Strand

Forward strand

Band

p15.4

Transcripts

ENST00000334619	ENSP00000335544
ENST00000532715	ENSP00000432079
ENST00000525014	ENSP00000437001
ENST00000531712	ENSP00000435675
ENST00000525462	ENSP00000435534
ENST00000532396

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0004951	cholecystokinin receptor activity
GO:0005515	protein binding
GO:0015054	gastrin receptor activity
GO:0031741	type B gastrin/cholecystokinin receptor binding
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity

Biological Process

GO:0001696	gastric acid secretion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007586	digestion
GO:0007600	sensory perception
GO:0007631	feeding behavior
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0038188	cholecystokinin signaling pathway
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0048565	digestive tract development
GO:0048732	gland development

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030898

View Gene Order

ENSBTAG00000005236

Not yet available

Pathways

NETPATH

REACTOME

REACT_18283

G alpha (q) signalling events pathway

REACT_120966

Gastrin-CREB signalling pathway via PKC and MAPK pathway

REACT_14819

Peptide ligand-binding receptors pathway

REACT_14828

Class A/1 (Rhodopsin-like receptors) pathway

REACT_14797

Signaling by GPCR pathway

REACT_111102

Signal Transduction pathway

REACT_19184

GPCR downstream signaling pathway

REACT_21340

GPCR ligand binding pathway

KEGG

hsa04080

Neuroactive ligand-receptor interaction pathway

hsa04020

Calcium signaling pathway pathway

hsa04971

Gastric acid secretion pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.203

RefSeq

NM_176875 XM_005253210

HUGO

OMIM

CCDS

CCDS7761

HPRD

00323

IMGT

EMBL

GenPept

RNA Seq Atlas