InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: CCKBR

Summary

InnateDB Protein

IDBP-28588.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CCKBR

Protein Name

cholecystokinin B receptor

Synonyms

CCK-B; CCK2R; GASR;

Species

Homo sapiens

Ensembl Protein

ENSP00000335544

InnateDB Gene

IDBG-28586 (CCKBR)

Protein Structure

UniProt Annotation

Function

Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system.Isoform 2 is constitutively activated and may regulate cancer cell proliferation via a gastrin-independent mechanism.

Subcellular Localization

Cell membrane; Multi-pass membrane protein.

Disease Associations

Tissue Specificity

Isoform 1 is expressed in brain, pancreas, stomach, the colon cancer cell line LoVo and the T-lymphoblastoma Jurkat, but not in heart, placenta, liver, lung, skeletal muscle, kidney or the stomach cancer cell line AGS. Expressed at high levels in the small cell lung cancer cell line NCI-H510, at lower levels in NCI-H345, NCI-H69 and GLC-28 cell lines, not expressed in GLC-19 cell line. Within the stomach, expressed at high levels in the mucosa of the gastric fundus and at low levels in the antrum and duodenum. Isoform 2 is present in pancreatic cancer cells and colorectal cancer cells, but not in normal pancreas or colonic mucosa. Isoform 3 is expressed in brain, pancreas, stomach, the stomach cancer cell line AGS and the colon cancer cell line LoVo. {ECO:0000269PubMed:10913157, ECO:0000269PubMed:12429993, ECO:0000269PubMed:7848914, ECO:0000269PubMed:7887934, ECO:0000269PubMed:8185170, ECO:0000269PubMed:8349705}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	9 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004435	phosphatidylinositol phospholipase C activity
GO:0004930	G-protein coupled receptor activity
GO:0004951	cholecystokinin receptor activity
GO:0005515	protein binding
GO:0015054	gastrin receptor activity
GO:0031741	type B gastrin/cholecystokinin receptor binding
GO:0046935	1-phosphatidylinositol-3-kinase regulator activity

Biological Process

GO:0001696	gastric acid secretion
GO:0007166	cell surface receptor signaling pathway
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007200	phospholipase C-activating G-protein coupled receptor signaling pathway
GO:0007204	positive regulation of cytosolic calcium ion concentration
GO:0007586	digestion
GO:0007600	sensory perception
GO:0007631	feeding behavior
GO:0008152	metabolic process
GO:0008283	cell proliferation
GO:0008284	positive regulation of cell proliferation
GO:0038188	cholecystokinin signaling pathway
GO:0043551	regulation of phosphatidylinositol 3-kinase activity
GO:0048565	digestive tract development
GO:0048732	gland development

Cellular Component

GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

InterPro

IPR000276 G protein-coupled receptor, rhodopsin-like
IPR000314 Gastrin receptor
IPR000611 Neuropeptide Y receptor family
IPR009126 Cholecystokinin receptor
IPR017452 GPCR, rhodopsin-like, 7TM
IPR019424 7TM GPCR, olfactory receptor/chemoreceptor Srsx

PFAM

PF00001
PF10320

PRINTS

PR00237
PR00527
PR01012
PR01822

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

P32239