Version 5.4
Homo sapiens Gene: ACAN
Summary
InnateDB Gene IDBG-28773.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACAN
Gene Name aggrecan
Synonyms AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK
Species Homo sapiens
Ensembl Gene ENSG00000157766
Encoded Proteins
IDBP-28779
aggrecan
IDBP-379946
aggrecan
IDBP-604191
aggrecan
IDBP-604192
aggrecan
IDBP-604193
aggrecan
IDBP-604194
aggrecan
IDBP-604195
aggrecan
IDBP-808082
aggrecan
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the aggrecan/versican proteoglycan family. The encoded protein is an integral part of the extracellular matrix in cartilagenous tissue and it withstands compression in cartilage. Mutations in this gene may be involved in skeletal dysplasia and spinal degeneration. Multiple alternatively spliced transcript variants that encode different protein isoforms have been observed in this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:88803443-88875354
Strand Forward strand
Band q26.1
Transcripts
ENST00000352105 ENSP00000341615
ENST00000439576 ENSP00000387356
ENST00000558207 ENSP00000453003
ENST00000559004 ENSP00000453499
ENST00000561243 ENSP00000453342
ENST00000560601 ENSP00000453581
ENST00000558704 ENSP00000452682
ENST00000558604
ENST00000617301 ENSP00000484456
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 6 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0005540 hyaluronic acid binding
GO:0030246 carbohydrate binding
Biological Process
GO:0001502 cartilage condensation
GO:0002063 chondrocyte development
GO:0007155 cell adhesion
GO:0030166 proteoglycan biosynthetic process
GO:0030199 collagen fibril organization
Cellular Component
GO:0005578 proteinaceous extracellular matrix
GO:0005604 basement membrane
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030607
View Gene Order
ENSBTAG00000016158
Not yet available
Pathways
NETPATH
NetPath_13
IL1 pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E7ENV9 E7EX88 H0YM81 Q6LE94 Q6PID9
UniProt Splice Variant
Entrez Gene 176
UniGene Hs.2159 Hs.616395
RefSeq NM_001135 NM_013227
HUGO HGNC:319
OMIM 155760
CCDS CCDS53970 CCDS53971
HPRD
IMGT
EMBL AC103982 BC036445 L29488
GenPept AAB48068 AAH36445
RNA Seq Atlas 176

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca