InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ACAN

Summary

InnateDB Protein

IDBP-379946.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ACAN

Protein Name

aggrecan

Synonyms

AGC1; AGCAN; CSPG1; CSPGCP; MSK16; SEDK;

Species

Homo sapiens

Ensembl Protein

ENSP00000387356

InnateDB Gene

IDBG-28773 (ACAN)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.

Experimentally validated
Total	7 [view]
Protein-Protein	6 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0030246	carbohydrate binding

Biological Process

GO:0001502	cartilage condensation
GO:0002063	chondrocyte development
GO:0007155	cell adhesion
GO:0030166	proteoglycan biosynthetic process
GO:0030199	collagen fibril organization

Cellular Component

GO:0005578	proteinaceous extracellular matrix
GO:0005604	basement membrane
GO:0031012	extracellular matrix

Protein Structure and Domains

PDB ID

InterPro

IPR000436 Sushi/SCR/CCP
IPR000538 Link
IPR000742 Epidermal growth factor-like domain
IPR001304 C-type lectin
IPR003596 Immunoglobulin V-set, subgroup
IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013106 Immunoglobulin V-set domain
IPR016187 C-type lectin fold

PFAM

PF00084
PF00193
PF00008
PF00059
PF07686

PRINTS

PR01265

PIRSF

SMART

SM00032
SM00445
SM00181
SM00034
SM00406
SM00409

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt