Version 5.4
Homo sapiens Gene: NUFIP1
Summary
InnateDB Gene IDBG-28958.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUFIP1
Gene Name nuclear fragile X mental retardation protein interacting protein 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000083635
Encoded Proteins
IDBP-28960
nuclear fragile X mental retardation protein interacting protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear RNA binding protein that contains a C2H2 zinc finger motif and a nuclear localization signal. This protein is associated with the nuclear matrix in perichromatin fibrils and, in neurons, localizes to the cytoplasm in association with endoplasmic reticulum ribosomes. This protein interacts with the fragile X mental retardation protein (FMRP), the tumor suppressor protein BRCA1, upregulates RNA polymerase II transcription, and is involved in box C/D snoRNP biogenesis. A pseudogene of this gene resides on chromosome 6q12. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:44939249-44989483
Strand Reverse strand
Band q14.12
Transcripts
ENST00000379161 ENSP00000368459
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein-Protein 23 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0030515 snoRNA binding
GO:0030674 protein binding, bridging
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0000492 box C/D snoRNP assembly
GO:0006396 RNA processing
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
Cellular Component
GO:0005634 nucleus
GO:0005726 perichromatin fibrils
GO:0005730 nucleolus
GO:0008023 transcription elongation factor complex
GO:0016363 nuclear matrix
GO:0022626 cytosolic ribosome
GO:0048786 presynaptic active zone
GO:0070761 pre-snoRNP complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022009
View Gene Order
ENSBTAG00000009415
Not yet available
Cross-References
SwissProt Q9UHK0
TrEMBL
UniProt Splice Variant
Entrez Gene 26747
UniGene Hs.525006 Hs.608948
RefSeq NM_012345
HUGO HGNC:8057
OMIM 604354
CCDS CCDS9393
HPRD 05073
IMGT
EMBL AF159548 AL354816 AL359706 BC017745
GenPept AAF15315 AAH17745 CAC40689 CAI12865
RNA Seq Atlas 26747

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca