InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ATP5A1

Summary

InnateDB Gene

IDBG-2902.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ATP5A1

Gene Name

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

Synonyms

ATP5A; ATP5AL2; ATPM; hATP1; HEL-S-123m; MC5DN4; MOM2; OMR; ORM

Species

Homo sapiens

Ensembl Gene

ENSG00000152234

Encoded Proteins

IDBP-2904

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

IDBP-232177

ATP synthase, H+ transporting, mitochondrial F1 complex, alpha subunit 1, cardiac muscle

IDBP-727393

IDBP-726602

IDBP-727489

IDBP-726016

IDBP-726124

IDBP-727653

IDBP-727465

IDBP-726089

IDBP-727551

IDBP-725536

IDBP-726013

IDBP-726781

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a subunit of mitochondrial ATP synthase. Mitochondrial ATP synthase catalyzes ATP synthesis, using an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. ATP synthase is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, comprising the proton channel. The catalytic portion of mitochondrial ATP synthase consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled with a stoichiometry of 3 alpha, 3 beta, and a single representative of the other 3. The proton channel consists of three main subunits (a, b, c). This gene encodes the alpha subunit of the catalytic core. Alternatively spliced transcript variants encoding the different isoforms have been identified. Pseudogenes of this gene are located on chromosomes 9, 2, and 16. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:46080248-46104334

Strand

Reverse strand

Band

q21.1

Transcripts

ENST00000282050	ENSP00000282050
ENST00000398752	ENSP00000381736
ENST00000590665	ENSP00000467037
ENST00000590324	ENSP00000465259
ENST00000591981	ENSP00000465805
ENST00000591267
ENST00000593152	ENSP00000465477
ENST00000590156	ENSP00000466309
ENST00000589869	ENSP00000465497
ENST00000586523
ENST00000590448
ENST00000588390
ENST00000592989	ENSP00000467830
ENST00000590406	ENSP00000468458
ENST00000589611
ENST00000592364	ENSP00000468618
ENST00000587902
ENST00000589252	ENSP00000466975
ENST00000586592	ENSP00000466275
ENST00000585650	ENSP00000467983

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 98 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	98 [view]
Protein-Protein	98 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016820	hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0016887	ATPase activity
GO:0022857	transmembrane transporter activity
GO:0042288	MHC class I protein binding
GO:0044822	poly(A) RNA binding
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism
GO:0046961	proton-transporting ATPase activity, rotational mechanism

Biological Process

GO:0001937	negative regulation of endothelial cell proliferation
GO:0006200	ATP catabolic process
GO:0006629	lipid metabolic process
GO:0006754	ATP biosynthetic process
GO:0009790	embryo development
GO:0015986	ATP synthesis coupled proton transport
GO:0015991	ATP hydrolysis coupled proton transport
GO:0015992	proton transport
GO:0022904	respiratory electron transport chain
GO:0042776	mitochondrial ATP synthesis coupled proton transport
GO:0044237	cellular metabolic process
GO:0044281	small molecule metabolic process
GO:0046034	ATP metabolic process

Cellular Component

GO:0005739	mitochondrion
GO:0005743	mitochondrial inner membrane
GO:0005753	mitochondrial proton-transporting ATP synthase complex
GO:0005759	mitochondrial matrix
GO:0005886	plasma membrane
GO:0008180	COP9 signalosome
GO:0016020	membrane
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain
GO:0045261	proton-transporting ATP synthase complex, catalytic core F(1)
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025428

View Gene Order

ENSBTAG00000002507

Not yet available

Pathways

NETPATH

REACTOME

REACT_118595

Mitochondrial protein import pathway

REACT_6759

Formation of ATP by chemiosmotic coupling pathway

REACT_6305

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway

REACT_17015

Metabolism of proteins pathway

REACT_111083

The citric acid (TCA) cycle and respiratory electron transport pathway

REACT_111217

Metabolism pathway

KEGG

hsa05010

Alzheimer's disease pathway

hsa00190

Oxidative phosphorylation pathway

hsa05012

Parkinson's disease pathway

hsa05016

Huntington's disease pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

K7EJP1 K7EQH4

UniProt Splice Variant

Entrez Gene

498

UniGene

Hs.298280 Hs.629138 Hs.707421

RefSeq

NM_001001935 NM_001001937 NM_001257334 NM_001257335 NM_004046

HUGO

HGNC:823

OMIM

164360

CCDS

CCDS11927 CCDS58620 CCDS59315

HPRD

01258

IMGT

EMBL

AC012569

GenPept

RNA Seq Atlas

498