Version 5.4
| Homo sapiens Gene: CCNE2 | |||||||||||||||||||
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| Summary | |||||||||||||||||||
| InnateDB Gene | IDBG-29174.6 | ||||||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
| Gene Symbol | CCNE2 | ||||||||||||||||||
| Gene Name | cyclin E2 | ||||||||||||||||||
| Synonyms | CYCE2 | ||||||||||||||||||
| Species | Homo sapiens | ||||||||||||||||||
| Ensembl Gene | ENSG00000175305 | ||||||||||||||||||
| Encoded Proteins |
cyclin E2
cyclin E2
cyclin E2
cyclin E2
cyclin E2
cyclin E2
cyclin E2
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| Protein Structure | |||||||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
| Entrez Gene | |||||||||||||||||||
| Summary |
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||||||
| Type | Protein coding | ||||||||||||||||||
| Genomic Location | Chromosome 8:94879770-94896678 | ||||||||||||||||||
| Strand | Reverse strand | ||||||||||||||||||
| Band | q22.1 | ||||||||||||||||||
| Transcripts | |||||||||||||||||||
| Interactions | |||||||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
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| Gene Ontology | |||||||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||||||
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Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||||||
| NETPATH | |||||||||||||||||||
| REACTOME |
p53-Dependent G1 DNA Damage Response pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G0 and Early G1 pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
Cyclin E associated events during G1/S transition pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Cellular responses to stress pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G1/S Transition pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cellular Senescence pathway
Cell Cycle, Mitotic pathway
G1/S DNA Damage Checkpoints pathway
Cell Cycle Checkpoints pathway
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| KEGG |
Cell cycle pathway
Small cell lung cancer pathway
Prostate cancer pathway
p53 signaling pathway pathway
Pathways in cancer pathway
Oocyte meiosis pathway
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| INOH | |||||||||||||||||||
| PID NCI | |||||||||||||||||||
| Cross-References | |||||||||||||||||||
| SwissProt | |||||||||||||||||||
| TrEMBL | Q8WUE3 | ||||||||||||||||||
| UniProt Splice Variant | |||||||||||||||||||
| Entrez Gene | 9134 | ||||||||||||||||||
| UniGene | Hs.521693 | ||||||||||||||||||
| RefSeq | NM_057749 | ||||||||||||||||||
| HUGO | HGNC:1590 | ||||||||||||||||||
| OMIM | 603775 | ||||||||||||||||||
| CCDS | CCDS6264 | ||||||||||||||||||
| HPRD | 04801 | ||||||||||||||||||
| IMGT | |||||||||||||||||||
| EMBL | AC087752 AP003692 BC020729 CH471060 | ||||||||||||||||||
| GenPept | AAH20729 EAW91727 | ||||||||||||||||||
| RNA Seq Atlas | 9134 | ||||||||||||||||||