Version 5.4
| Mus musculus Gene: Ccne2 | |||||||||||||||
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| Summary | |||||||||||||||
| InnateDB Gene | IDBG-129263.6 | ||||||||||||||
| Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||
| Gene Symbol | Ccne2 | ||||||||||||||
| Gene Name | cyclin E2 | ||||||||||||||
| Synonyms | |||||||||||||||
| Species | Mus musculus | ||||||||||||||
| Ensembl Gene | ENSMUSG00000028212 | ||||||||||||||
| Encoded Proteins |
cyclin E2
cyclin E2
cyclin E2
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| Protein Structure | |||||||||||||||
| Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||
| Entrez Gene | |||||||||||||||
| Summary |
This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000175305:
The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK2. This cyclin has been shown to specifically interact with CIP/KIP family of CDK inhibitors, and plays a role in cell cycle G1/S transition. The expression of this gene peaks at the G1-S phase and exhibits a pattern of tissue specificity distinct from that of cyclin E1. A significantly increased expression level of this gene was observed in tumor-derived cells. [provided by RefSeq, Jul 2008] |
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| Gene Information | |||||||||||||||
| Type | Protein coding | ||||||||||||||
| Genomic Location | Chromosome 4:11191351-11204779 | ||||||||||||||
| Strand | Forward strand | ||||||||||||||
| Band | A1 | ||||||||||||||
| Transcripts |
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| Interactions | |||||||||||||||
| Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
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| Gene Ontology | |||||||||||||||
Molecular Function |
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| Biological Process |
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| Cellular Component |
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| Orthologs | |||||||||||||||
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Species
Homo sapiens
Bos taurus
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Gene ID
Gene Order
Not yet available
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| Pathways | |||||||||||||||
| NETPATH | |||||||||||||||
| REACTOME |
Cell Cycle, Mitotic pathway
Cellular responses to stress pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G0 and Early G1 pathway
DNA Damage/Telomere Stress Induced Senescence pathway
p53-Dependent G1 DNA Damage Response pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Cell Cycle pathway
Cell Cycle Checkpoints pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
Cellular Senescence pathway
G1/S DNA Damage Checkpoints pathway
G1/S Transition pathway
Mitotic G1-G1/S phases pathway
Cyclin E associated events during G1/S transition pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
S Phase pathway
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| KEGG |
p53 signaling pathway pathway
Cell cycle pathway
Small cell lung cancer pathway
Prostate cancer pathway
Pathways in cancer pathway
Oocyte meiosis pathway
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| INOH | |||||||||||||||
| PID NCI | |||||||||||||||
| Pathway Predictions based on Human Orthology Data | |||||||||||||||
| NETPATH | |||||||||||||||
| REACTOME |
p53-Dependent G1 DNA Damage Response pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
G0 and Early G1 pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
Cyclin E associated events during G1/S transition pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Cellular responses to stress pathway
Mitotic G1-G1/S phases pathway
S Phase pathway
G1/S Transition pathway
Cell Cycle pathway
DNA Damage/Telomere Stress Induced Senescence pathway
Cellular Senescence pathway
Cell Cycle, Mitotic pathway
G1/S DNA Damage Checkpoints pathway
Cell Cycle Checkpoints pathway
G0 and Early G1 pathway
S Phase pathway
Mitotic G1-G1/S phases pathway
Phosphorylation of proteins involved in G1/S transition by active Cyclin E:Cdk2 complexes pathway
G1/S DNA Damage Checkpoints pathway
G1/S Transition pathway
Cellular responses to stress pathway
Cell Cycle, Mitotic pathway
Cell Cycle pathway
Cellular Senescence pathway
Cyclin E associated events during G1/S transition pathway
SCF(Skp2)-mediated degradation of p27/p21 pathway
p53-Dependent G1 DNA Damage Response pathway
Cyclin A:Cdk2-associated events at S phase entry pathway
p53-Dependent G1/S DNA damage checkpoint pathway
Cell Cycle Checkpoints pathway
DNA Damage/Telomere Stress Induced Senescence pathway
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| KEGG |
Cell cycle pathway
Small cell lung cancer pathway
Prostate cancer pathway
p53 signaling pathway pathway
Pathways in cancer pathway
Oocyte meiosis pathway
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| INOH | |||||||||||||||
| PID NCI | |||||||||||||||
| Cross-References | |||||||||||||||
| SwissProt | |||||||||||||||
| TrEMBL | |||||||||||||||
| UniProt Splice Variant | |||||||||||||||
| Entrez Gene | |||||||||||||||
| UniGene | Mm.35867 | ||||||||||||||
| RefSeq | NM_001037134 NM_001282943 NM_009830 XM_006537573 XM_006537575 | ||||||||||||||
| OMIM | |||||||||||||||
| CCDS | CCDS17965 CCDS17966 | ||||||||||||||
| HPRD | |||||||||||||||
| IMGT | |||||||||||||||
| MGI ID | |||||||||||||||
| MGI Symbol | |||||||||||||||
| EMBL | |||||||||||||||
| GenPept | |||||||||||||||
| RNA Seq Atlas | |||||||||||||||