Version 5.4
Homo sapiens Gene: IBSP
Summary
InnateDB Gene IDBG-29240.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IBSP
Gene Name integrin-binding sialoprotein
Synonyms BNSP; BSP; BSP-II; SP-II
Species Homo sapiens
Ensembl Gene ENSG00000029559
Encoded Proteins
IDBP-29242
integrin-binding sialoprotein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12%% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:87799581-87812435
Strand Forward strand
Band q22.1
Transcripts
ENST00000226284 ENSP00000226284
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0001503 ossification
GO:0001649 osteoblast differentiation
GO:0007155 cell adhesion
GO:0030198 extracellular matrix organization
GO:0031214 biomineral tissue development
GO:0071363 cellular response to growth factor stimulus
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0031988 membrane-bounded vesicle
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000029306
View Gene Order
ENSBTAG00000000470
Not yet available
Pathways
NETPATH
REACTOME
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_163906
ECM proteoglycans pathway
KEGG
hsa04512
ECM-receptor interaction pathway
hsa04510
Focal adhesion pathway
INOH
PID NCI
integrin3_pathway
Beta3 integrin cell surface interactions
Cross-References
SwissProt P21815
TrEMBL
UniProt Splice Variant
Entrez Gene 3381
UniGene Hs.518726
RefSeq NM_004967
HUGO HGNC:5341
OMIM 147563
CCDS CCDS3624
HPRD
IMGT
EMBL AC093768 J05213 L09554 L09555 L09556 L09557 L09558 L24757 L24759
GenPept AAA60549 AAC37560 AAC95490
RNA Seq Atlas 3381

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca