InnateDB: Systems Biology of the Innate Immune Response

Bos taurus Gene: IBSP

Summary

InnateDB Gene

IDBG-641213.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IBSP

Gene Name

Bone sialoprotein 2

Synonyms

Species

Bos taurus

Ensembl Gene

ENSBTAG00000000470

Encoded Proteins

IDBP-693543

Bone sialoprotein 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000029559:
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a major structural protein of the bone matrix. It constitutes approximately 12%% of the noncollagenous proteins in human bone and is synthesized by skeletal-associated cell types, including hypertrophic chondrocytes, osteoblasts, osteocytes, and osteoclasts. The only extraskeletal site of its synthesis is the trophoblast. This protein binds to calcium and hydroxyapatite via its acidic amino acid clusters, and mediates cell attachment through an RGD sequence that recognizes the vitronectin receptor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:38309555-38323305

Strand

Reverse strand

Band

Transcripts

ENSBTAT00000000595

ENSBTAP00000000595

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0001503	ossification
GO:0001649	osteoblast differentiation
GO:0007155	cell adhesion
GO:0030198	extracellular matrix organization
GO:0030282	bone mineralization
GO:0031214	biomineral tissue development
GO:0071363	cellular response to growth factor stimulus