Version 5.4
Homo sapiens Gene: PIWIL3
Summary
InnateDB Gene IDBG-2931.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIWIL3
Gene Name piwi-like 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000184571
Encoded Proteins
IDBP-2933
piwi-like 3 (Drosophila)
IDBP-596426
piwi-like 3 (Drosophila)
IDBP-587371
piwi-like 3 (Drosophila)
IDBP-806267
piwi-like RNA-mediated gene silencing 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the PIWI subfamily of Argonaute family proteins. This subfamily of proteins contains a PAZ domain, found in proteins involved in RNA-mediated gene silencing, and a C-terminal Piwi domain. The encoded protein is thought to function in maintenance of germline cells. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 22:24719034-24774720
Strand Reverse strand
Band q11.23
Transcripts
ENST00000332271 ENSP00000330031
ENST00000533313 ENSP00000431843
ENST00000527701 ENSP00000435718
ENST00000532537
ENST00000616349 ENSP00000479524
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0005515 protein binding
Biological Process
GO:0006417 regulation of translation
GO:0007126 meiotic nuclear division
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0031047 gene silencing by RNA
Cellular Component
GO:0005737 cytoplasm
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04320
Dorso-ventral axis formation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E9PIP6
UniProt Splice Variant
Entrez Gene 440822
UniGene Hs.448343 Hs.739751
RefSeq NM_001008496 NM_001255975
HUGO HGNC:18443
OMIM 610314
CCDS CCDS33623
HPRD 17855
IMGT
EMBL AP000358 AP000359
GenPept
RNA Seq Atlas 440822

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca