InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PIWIL3

Summary

InnateDB Protein

IDBP-2933.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PIWIL3

Protein Name

piwi-like 3 (Drosophila)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000330031

InnateDB Gene

IDBG-2931 (PIWIL3)

Protein Structure

UniProt Annotation

Function

May play a role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Besides their function in transposable elements repression, piRNAs are probably involved in other processes during meiosis such as translation regulation (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm. Note=Probable component of the meiotic nuage, also named P granule, a germ-cell-specific organelle required to repress transposon activity during meiosis. {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in testis. {ECO:0000269PubMed:12906857}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding

Biological Process

GO:0006417	regulation of translation
GO:0007126	meiotic nuclear division
GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation
GO:0031047	gene silencing by RNA